prop-2-enyl (6S,7S)-8-oxo-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-7-(tritylamino)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | 1393717-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: prop-2-enyl (6S,7S)-8-oxo-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-7-(tritylamino)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 1393717-49-1
• 化学式: C₃₂H₂₈N₄O₄S₂
• 分子量: 596.731
• InChiKey: ATXKPKJZEBKONR-VPUSJEBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  prop-2-enyl (6S,7S)-8-oxo-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-7-(tritylamino)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 36.0h， 生成 prop-2-enyl (6S,7S)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-cyclopentyloxyiminoacetyl]amino]-8-oxo-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems

  摘要：

  A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a [2-(5-amino-1,2,4-thiadizol-3-yl)-2-(Z)-alkoxyimino]acetamido moiety at 7-position were synthesized and tested for their antibacterial activities. The analogs 17c and 17f have well-balanced potency and significantly enhanced activity as compared with the reference compound ceftazidime. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.040
• 作为产物：
  描述：

  烯丙基2-溴乙酸乙酯 在 偶氮二甲酸二异丙酯 、 四丁基氟化铵 、 四丁基溴化铵 、 sodium hexamethyldisilazane 、 三苯基膦 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 0.75h， 生成 prop-2-enyl (6S,7S)-8-oxo-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-7-(tritylamino)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems

  摘要：

  A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a [2-(5-amino-1,2,4-thiadizol-3-yl)-2-(Z)-alkoxyimino]acetamido moiety at 7-position were synthesized and tested for their antibacterial activities. The analogs 17c and 17f have well-balanced potency and significantly enhanced activity as compared with the reference compound ceftazidime. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.040

文献信息

• Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems
  作者：Jianbo Wu、Xueying Wu、Fan Lei、Huajie Yuan、Li Hai、Yong Wu

  DOI：10.1016/j.bmcl.2012.06.040

  日期：2012.8

  A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a [2-(5-amino-1,2,4-thiadizol-3-yl)-2-(Z)-alkoxyimino]acetamido moiety at 7-position were synthesized and tested for their antibacterial activities. The analogs 17c and 17f have well-balanced potency and significantly enhanced activity as compared with the reference compound ceftazidime. (C) 2012 Elsevier Ltd. All rights reserved.