2-(7-Chloro-3,4-dihydro-naphthalen-2-yl)-6-methyl-pyridin-4-yl-amine fumarate | 521917-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(7-Chloro-3,4-dihydro-naphthalen-2-yl)-6-methyl-pyridin-4-yl-amine fumarate
• 英文别名: (E)-but-2-enedioic acid;2-(7-chloro-3,4-dihydronaphthalen-2-yl)-6-methylpyridin-4-amine
• CAS: 521917-30-6
• 化学式: C₄H₄O₄*C₁₆H₁₅ClN₂
• 分子量: 386.835
• InChiKey: RZQPVICHXQKTHU-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-溴-6-甲基吡啶-4-胺 、 7-chloro-3,4-dihydro-naphthalene-2-boronic acid 在 四(三苯基膦)钯 potassium carbonate 作用下， 生成 2-(7-Chloro-3,4-dihydro-naphthalen-2-yl)-6-methyl-pyridin-4-yl-amine fumarate
  参考文献：
  名称：

  Conjugated aromatic compounds with a pyridine substituent

  摘要：

  本发明涉及以下式1的化合物。本发明的化合物是NMDA（N-甲基-D-天冬氨酸）受体亚型阻断剂，用于治疗与该受体相关的疾病。

  公开号：

  US20030144525A1

文献信息

• PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1443926A1

  公开（公告）日：2004-08-11
• US6951875B2
  申请人：——

  公开号：US6951875B2

  公开（公告）日：2005-10-04
• US7034044B2
  申请人：——

  公开号：US7034044B2

  公开（公告）日：2006-04-25
• [EN] PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS<br/>[FR] DERIVES DE PYRIDINE EN TANT QUE BLOQUANTS D'UN SOUS-TYPE DU RECEPTEUR NMDA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003037333A1

  公开（公告）日：2003-05-08

  The present invention relates to compounds of formulas (IA) or (IB) wherein R1/R2 independently from each other hydrogen, lower alkyl, -(CH2)nNR5R5' or -(CH2)n+1OH; R5 and R5' are independently from each hydrogen, lower alkyl; R3/R4 are independently from each other hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl or hydroxy; Ar is phenyl or thiophenyl; the dotted line is -CH2-CH2-, -CH2-CHR'-, wherein R' is lower alkyl or are two hydrogen atoms, not forming a bridge and; n is 0, 1 or 2; and to pharmaceutically acceptable acid addition salts thereof, with the exception of 6-styryl-pyridin-2-yl-amine. The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and may be used in the treatment of diseases related to this receptor.
• Conjugated aromatic compounds with a pyridine substituent
  申请人：——

  公开号：US20030144525A1

  公开（公告）日：2003-07-31

  The present invention relates to compounds of formulae 1 The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.

  本发明涉及以下式1的化合物。本发明的化合物是NMDA（N-甲基-D-天冬氨酸）受体亚型阻断剂，用于治疗与该受体相关的疾病。