[3-(9H-Fluoren-9-ylmethyl)-2,4-dioxo-thiazolidin-5-yl]-acetic acid | 313271-29-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: [3-(9H-Fluoren-9-ylmethyl)-2,4-dioxo-thiazolidin-5-yl]-acetic acid
• 英文别名: 2-[3-(9H-fluoren-9-ylmethyl)-2,4-dioxo-1,3-thiazolidin-5-yl]acetic acid
• CAS: 313271-29-3
• 化学式: C₁₉H₁₅NO₄S
• 分子量: 353.398
• InChiKey: XVVMLIIDHJVJJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fmoc-L-亮氨酸 、 [3-(9H-Fluoren-9-ylmethyl)-2,4-dioxo-thiazolidin-5-yl]-acetic acid 生成 (S)-2-{(S)-2-[2-(2,4-Dioxo-thiazolidin-5-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6
• 作为产物：
  描述：

  5-Allyl-3-(9H-fluoren-9-ylmethyl)-thiazolidine-2,4-dione 在 jones reagent 、 臭氧 作用下， 生成 [3-(9H-Fluoren-9-ylmethyl)-2,4-dioxo-thiazolidin-5-yl]-acetic acid
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6

文献信息

• Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands
  作者：Debra L Mohler、Gang Shen、Anthony K Dotse

  DOI：10.1016/s0960-894x(00)00440-6

  日期：2000.10

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.