[EN] 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DERIVATIVES FOR USE AS BETA-3 ADRENORECEPTOR AGONISTS IN THE TREATMENT OF UROLOGICAL AND INFLAMMATORY DISORDERS<br/>[FR] DERIVES DE 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DESTINES A ETRE UTILISES EN TANT QU'AGONISTES DU RECEPTEUR ADRENERGIQUE BETA-3 DANS LE TRAITEMENT DE TROUBLES UROLOGIQUES ET INFLAMMATOIRES
申请人:BAYER HEALTHCARE AG
公开号:WO2005056544A1
公开(公告)日:2005-06-23
This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.
这项发明涉及公式(I)的类胡萝卜素衍生物及其盐,其可用作药物制剂的活性成分。本发明的类胡萝卜素衍生物作为BETA 3拮抗剂具有出色的活性,并可用于预防和治疗与BETA 3活性相关的疾病,特别是用于治疗泌尿系统紊乱或疾病,如膀胱过度活动(过度活跃膀胱)、尿失禁、神经源性膀胱过度活动(膀胱过度反射)、特发性膀胱过度活动(膀胱不稳定)、良性前列腺增生和下尿路症状;以及炎症性疾病,如哮喘和慢性阻塞性肺病(COPD)。