2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-oxy>-N-n-propyl-ethylamine | 140367-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-oxy>-N-n-propyl-ethylamine
• 英文别名: N-[2-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)oxy]ethyl]propan-1-amine
• CAS: 140367-04-0
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.38
• InChiKey: YZYDTLPROPRTMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  阿戈美拉汀杂质醇(A) 在 氯化亚砜 、 sodium hydride 作用下， 以 甲苯 为溶剂， 生成 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-oxy>-N-n-propyl-ethylamine
  参考文献：
  名称：

  Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines

  摘要：

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.

  DOI：

  10.1016/0223-5234(91)90129-b

文献信息

• Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines
  作者：R Perrone、F Berardi、V Tortorella、S Govoni、MD Lograno、E Daniele

  DOI：10.1016/0223-5234(91)90129-b

  日期：1991.12

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.