(2S)-2-[4-(acetylamino)phenyl]propanoic acid | 942047-59-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2S)-2-[4-(acetylamino)phenyl]propanoic acid
• 英文别名: (S)-2-(4-acetylamino-phenyl)-propionic acid；(S)-2-(4-Acetylamino-phenyl)-propionsaeure；(2S)-2-(4-acetamidophenyl)propanoic acid
• CAS: 942047-59-8
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: QIMLDDVXSIWEKG-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-isopropyl-1,3-[2-¹⁴C]thiazol-2-amine 、 (2S)-2-[4-(acetylamino)phenyl]propanoic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (2S)-2-(4-acetamidophenyl)-N-(5-propan-2-yl-(214C)1,3-thiazol-2-yl)propanamide
  参考文献：
  名称：

  Synthesis of PHA-690509 labelled with14C

  摘要：

  PHA-690509 是一种细胞周期蛋白依赖性激酶 A 抑制剂，已用碳-14 标记。[14C]PHA-690509由[14C]硫脲3开始，通过三步程序获得，总放射化学收率为10%。Copyright © 2007 John Wiley & Sons, Ltd. All Rights Reserved.

  DOI：

  10.1002/jlcr.1253
• 作为产物：
  描述：

  (S)-4-硝基苯基-2-丙酸 在 甲醇 、 铂 作用下， 生成 (2S)-2-[4-(acetylamino)phenyl]propanoic acid
  参考文献：
  名称：

  A separation method for DNA computing based on concentration control

  摘要：

  A separation method for DNA computing based on concentration control is presented. The concentration control method was earlier developed and has enabled us to use DNA concentrations as input data and as filters to extract target DNA. We have also applied the method to the shortest path problems, and have shown the potential of concentration control to solve large-scale combinatorial optimization problems. However, it is still quite difficult to separate different DNA with the same length and to quantify individual DNA concentrations. To overcome these difficulties, we use DGGE and CDGE in this paper. We demonstrate that the proposed method enables us to separate different DNA with the same length efficiently, and we actually solve an instance of the shortest path problems.

  DOI：

  10.1007/bf03037359

文献信息

• Dynamic changes in cardiac fatty acid metabolism in the stunned human myocardium
  作者：Kazuki Ito、Hiroki Sugihara、Tatsuya Kawasaki、Shuji Katoh、Akihiro Azuma、Masao Nakagawa

  DOI：10.1007/bf02988241

  日期：2001.8

  Background: The chronological changes or mechanisms in cardiac fatty acid metabolism under clinical conditions of hypoxia and ischemia have not been fully elucidated. I-123-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) can be used with single photon emission computed tomography (SPECT) to evaluate myocardial fatty acid metabolism. We investigated chronological changes in energy metabolism in the stunned human myocardium by means of I-123-BMIPP myocardial SPECT.Methods and Results: We conducted I-123-BMIPP myocardial SPECT in 10 patients with stunned myocardium during the acute, subacute and chronic phases after onset. The left ventricle was divided into 9 regions on SPECT, and the degree of abnormalities in each region was scored in four grades from normal (0) to defect (4). We also examined wash-out rates on BMIPP images. The scores on early BMIPP images in the acute, subacute and chronic phases were 5.6 +/- 1.8, 13.4 +/- 3.5 and 2.5 +/- 1.1, respectively, and the score was highest in the subacute phase (p < 0.001). Similarly, scores on the late images were 2.3 +/- 1.7, 18.3 +/- 4.5 and 4.7 +/- 2.6, respectively, and highest in the subacute phase (p < 0.001). The wash-out rates (normal: 18.2 +/- 2.1%) in the acute, subacute and chronic phases were 12.1 +/- 4.8%, 44.9 +/- 10.0% and 23.1 +/- 4.6%, respectively, with the value being lowest during the acute phase (p < 0.05), and highest during the subacute phase (p < 0.001).Conclusion: These results suggested that fatty acid metabolism in the stunned human myocardium changes dynamically over time.
• Synthesis of PHA-690509 labelled with14C
  作者：E. Fontana、D. Giribone、C. Felicini

  DOI：10.1002/jlcr.1253

  日期：2007.3.30

  PHA-690509, a cyclin-dependent kinase A inhibitor, has been labelled with carbon-14. [14C]PHA-690509 was obtained via a three-step procedure in 10% overall radiochemical yield starting from [14C]thiourea 3. Copyright © 2007 John Wiley & Sons, Ltd.

  PHA-690509 是一种细胞周期蛋白依赖性激酶 A 抑制剂，已用碳-14 标记。[14C]PHA-690509由[14C]硫脲3开始，通过三步程序获得，总放射化学收率为10%。Copyright © 2007 John Wiley & Sons, Ltd. All Rights Reserved.
• A separation method for DNA computing based on concentration control
  作者：Masahito Yamamoto、Atsushi Kameda、Nobuo Matsuura、Toshikazu Shiba、Yumi Kawazoe、Azuma Ohuchi

  DOI：10.1007/bf03037359

  日期：2002.9

  A separation method for DNA computing based on concentration control is presented. The concentration control method was earlier developed and has enabled us to use DNA concentrations as input data and as filters to extract target DNA. We have also applied the method to the shortest path problems, and have shown the potential of concentration control to solve large-scale combinatorial optimization problems. However, it is still quite difficult to separate different DNA with the same length and to quantify individual DNA concentrations. To overcome these difficulties, we use DGGE and CDGE in this paper. We demonstrate that the proposed method enables us to separate different DNA with the same length efficiently, and we actually solve an instance of the shortest path problems.