2,8-dimethyl-1,7-dihydro-purine-6-thione | 89853-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2,8-dimethyl-1,7-dihydro-purine-6-thione
• 英文别名: 2,8-Dimethyl-1,7-dihydro-purin-6-thion；2,8-Dimethyl-3,7-dihydropurine-6-thione
• CAS: 89853-26-9
• 化学式: C₇H₈N₄S
• 分子量: 180.233
• InChiKey: CMSZIDOUZMDYIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,8-dimethyl-1,7-dihydro-purine-6-thione 、 碘甲烷 在 sodium hydroxide 作用下， 生成 2,8-dimethyl-6-methylsulfanyl-7(9)H-purine
  参考文献：
  名称：

  Craveri; Zoni, Chimica, 1958, vol. 34, p. 185,188,190

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(6-氨基-2-甲基-4-氧代-1H-嘧啶-5-基)乙酰胺 在 乙醇 、 三氯氧磷 作用下， 生成 2,8-dimethyl-1,7-dihydro-purine-6-thione
  参考文献：
  名称：

  Potential Purine Antagonists. XVI. Preparation of Some 2-, 6- and 8-Methylpurines¹

  摘要：

  DOI：

  10.1021/ja01510a044

文献信息

• Craveri; Zoni, Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1958, vol. 16, p. 89
  作者：Craveri、Zoni

  DOI：——

  日期：——
• POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER
  申请人：Zhao Hong

  公开号：US20120289571A1

  公开（公告）日：2012-11-15

  The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.
• US7393953B2
  申请人：——

  公开号：US7393953B2

  公开（公告）日：2008-07-01
• [EN] POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER<br/>[FR] CONJUGUÉS POLYMÈRES DE COMPOSÉS CONTENANT UN GROUPEMENT AMINE AROMATIQUE COMPRENANT UN LIEUR D'URÉE LIBÉRABLE
  申请人：ENZON PHARMACEUTICALS INC

  公开号：WO2011082368A2

  公开（公告）日：2011-07-07

  The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.
• Potential Purine Antagonists. XVI. Preparation of Some 2-, 6- and 8-Methylpurines¹
  作者：Raj N. Prasad、C. Wayne Noell、Roland K. Robins

  DOI：10.1021/ja01510a044

  日期：1959.1