2-Hydroxymethyl-chinoxalin-1,4-dioxid | 20492-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Hydroxymethyl-chinoxalin-1,4-dioxid
• 英文别名: 2-Hydroxymethylquinoxaline 1,4-dioxide；(1-oxido-4-oxoquinoxalin-4-ium-2-yl)methanol
• CAS: 20492-05-1
• 化学式: C₉H₈N₂O₃
• 分子量: 192.174
• InChiKey: FLWOWDJSGNGQFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Hydroxymethyl-chinoxalin-1,4-dioxid 生成 1,4-Di-N-oxy-2-acetoxymethyl-chinoxalin
  参考文献：
  名称：

  YOUNG, VERNON;BRIGHT, DAVID R.

  摘要：

  DOI：
• 作为产物：
  描述：

  喹噁啉-2-甲醇 在 吡啶 、 盐酸 、 过氧乙酸 、 溶剂黄146 作用下， 生成 2-Hydroxymethyl-chinoxalin-1,4-dioxid
  参考文献：
  名称：

  403.喹喔啉N-氧化物。第四部分 Py-羟烷基-，-氨基烷基-和-羧基-喹喔啉的衍生物

  摘要：

  DOI：

  10.1039/jr9560002052

文献信息

• 1,4-Dioxo- and 4-oxoquinoxaline-2-carboxaldehyde sulfonylhydrazones and
  申请人：Pfizer Inc.

  公开号：US04100284A1

  公开（公告）日：1978-07-11

  The invention relates to novel chemical compounds which have useful antibacterial properties and are also of value in promoting animal growth and improving animal feed efficiency. More specifically, these new chemical compounds are certain sulfonylhydrazones of 1,4-dioxoquinoxaline-2-carboxaldehyde, 4-oxoquinoxaline-2-carboxaldehyde and certain derivatives thereof of formula (I): ##STR1## wherein A is N or N .fwdarw. O; R is a member selected from the group consisting of alkyl having from one to five carbon atoms, trifluoromethyl, phenyl, npahthyl, benzyl, styryl and phenyl substituted by up to two members selected from the group consisting of Cl, F, Br, CH.sub.3, CH.sub.3 O and NO.sub.2 ; R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or methyl; R.sup.3 is a 6- or 7-position substituent and is selected from the group H, Cl, CH.sub.3, CH.sub.3 O, SO.sub.2 NH.sub.2, SO.sub.2 NHCH.sub.3 and SO.sub.2 N(CH.sub.3).sub.2 ; R.sup.4 is a 7- or 6-position substituent and is selected from the group H, Cl and CH.sub.3 ; with the proviso that when R.sup.4 is Cl or CH.sub.3, R.sup.3 and R.sup.4 are the same.

  该发明涉及具有有用的抗菌性能的新型化合物，同时在促进动物生长和改善动物饲料效率方面也具有价值。更具体地说，这些新的化合物是1,4-二氧化喹啉-2-羧醛的某些磺基脒酮，4-氧喹啉-2-羧醛及其某些衍生物的化合物，其化学式为(I)：##STR1## 其中A为N或N→O；R为从含有一至五个碳原子的烷基、三氟甲基、苯基、萘基、苄基、苯乙烯基和苯基中选择的一种成员；R1为氢或甲基；R2为氢或甲基；R3为6-或7-位置取代基，选择自H、Cl、CH3、 O、SO2NH2、SO2NH 和SO2N( )2的群组中；R4为7-或6-位置取代基，选择自H、Cl和 的群组中；但当R4为Cl或 时，R3和R4相同。
• US3966951A
  申请人：——

  公开号：US3966951A

  公开（公告）日：1976-06-29
• US4100284A
  申请人：——

  公开号：US4100284A

  公开（公告）日：1978-07-11
• US4511717A
  申请人：——

  公开号：US4511717A

  公开（公告）日：1985-04-16
• [EN] 2-HYDROXYMETHYL-QUINOXALINE-1,4-DIOXIDE DERIVATIVES,A PROCESS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME
  申请人：EGYT GYÓGYSZERVEGYÉSZETI GYÁR

  公开号：WO1982001001A1

  公开（公告）日：1982-04-01

  (EN) New 2-hydroxymethyl-quinoxaline-1, 4-dioxide derivatives of the general formula (I) (FORMULA) wherein A represents an amino group, or a group of the general formula -NH-COOR1, wherein R1 stands for a C2-4 alkyl group, or a group of the general formula -NH-CX-NH2, wherein X denotes an oxygen or sulfur atom, or a group of the formula -NH-C(NH)-NH2, or a group of the general formula -NH-R2, wherein R2 represents a C1-6 alkyl, a phenyl, a benzyl, a hydroxyl or a hydroxy-(C2-4alkyl) group, or a group of the general formula -NH-CO-R3, wherein R3 stands for a C1-20 alkyl group or a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of nitro, hydroxyl, amino, C1-3 alkoxy and halogen; a naphtyl group optionally substituted by a hydroxyl group a phenyl- (C1-3 alkyl) group, a pyridyl, a piperidyl, a pyrazinyl, a pyrimidyl, a 1,2,4-triazinyl, a furyl, a nitrofuryl or an (Alpha),(Alpha)-diphenyl-(Alpha)-hydroxymethyl group. Due to their antimicrobial and weight-gain increasing effects, the new compounds of the general formula (I) can serve as active ingredients of pharmaceutical or veterinary compositions, particularly fodder concentrates, fodder additives and fodders. The invention relates also to the preparation of the new compounds of the general formula (I) and the compositions containing same. (FR) Nouveaux derives de 2-hydroxymethyl-quinoxaline-1,4-bioxyde selon la formule generale (I) (FORMULE) ou A represente un groupe amino, ou un groupe selon la formule generale -NH-COOR1, ou R1 represente un groupe alkyle C2-4, ou un groupe selon la formule generale -NH-CX-NH2, ou X represente un atome d'oxygene ou de soufre, ou un groupe selon la formule - NH-C (NH)-NH2, ou un groupe selon la formule generale-NH-R2, ou R2 represente un groupe alkyle C1-6, un groupe phenyle, un groupe benzyle, un groupe hydroxyle ou un groupe hydroxy- (C2-4 alkyle), ou un groupe selon la formule generale -NH-COR3, ou R3 represente un groupe alkyle C1-20 ou un groupe phenyle facultativement substitue par 1, 2 ou 3 substituant(s) identique(s) ou different(s) choisi(s) dans le groupe se composant de nitro, hydroxyle, amino, C1-3 alcoxy et halogene; un groupe naphtyle substitue facultativement par un groupe hydroxyle, un groupe phenyle-(C1-3 alkyle), un groupe pyridile, un groupe piperydile, un groupe pyrazinile, un groupe pyridinile, un groupe 1,2,4-triazinile, un groupe furyle, un groupe nitrofuryle ou un groupe (Alpha), (Alpha)-biphenyle-(Alpha)-hydroxymethyle. A cause de leur action antimicrobienne et stimulant l'augmentation de poids, ces nouveaux composes selon la formule generale (1) peuvent etre utilises comme ingredients actifs dans des compositions pharmaceutiques ou veterinaires, notamment dans des concentres de fourrage, dans des additifs de fourrage et dans des fourrages. La preparation des nouveaux composes selon la formule generale (1) et les compositions les contenant sont aussi decrites.