alpha-[(乙基氨基)甲基]-4-羟基苄醇 | 4232-09-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: alpha-[(乙基氨基)甲基]-4-羟基苄醇
• 英文名称: 2-ethylamino-1-(4-hydroxy-phenyl)-ethanol
• 英文别名: 2-Aethylamino-1-(4-hydroxy-phenyl)-aethanol；alpha-(Ethylaminomethyl)-p-hydroxybenzyl alcohol；4-[2-(ethylamino)-1-hydroxyethyl]phenol
• CAS: 4232-09-1
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: MQRWHXKOHDDQGC-UHFFFAOYSA-N

物化性质

• 沸点：
  351.7±27.0 °C(Predicted)
• 密度：
  1.127±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922509090

反应信息

• 作为产物：
  描述：

  4-(2-bromoacetyl)phenyl benzoate 在 palladium on activated charcoal 、 水 、 异丙醇 作用下， 生成 alpha-[(乙基氨基)甲基]-4-羟基苄醇
  参考文献：
  名称：

  Preparation of N-Substituted 1-(p-Hydroxyphenyl)-2-aminoethanols¹

  摘要：

  DOI：

  10.1021/ja01227a004

文献信息

• Synthesis and uses of synephrine derivatives
  申请人：Chen Jian

  公开号：US20050250944A1

  公开（公告）日：2005-11-10

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β 3 -adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.

  本发明公开了一种新型合成橙皮碱、其衍生物和上述衍生物的盐，包括它们的中间体。橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物。橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病、症状或紊乱。它们通常用作脂肪分解剂和/或减肥剂。
• [EN] SYNTHESIS AND USES OF SYNEPHRINE DERIVATIVES<br/>[FR] SYNTHESE ET UTILISATIONS DE DERIVES DE SYNEPHRINE
  申请人：SYNTECH SSPF INTERNAT INC

  公开号：WO2005108381A1

  公开（公告）日：2005-11-17

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β3-adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.
• Preparation of N-Substituted 1-(p-Hydroxyphenyl)-2-aminoethanols¹
  作者：John R. Corrigan、Marie-Jo Langerman、Maurice L. Moore

  DOI：10.1021/ja01227a004

  日期：1945.11