Diethyl (1-hydroxy-2-methylpyrrolidin-2-yl)phosphonate | 189149-51-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Diethyl (1-hydroxy-2-methylpyrrolidin-2-yl)phosphonate
• 英文别名: 2-Diethoxyphosphoryl-1-hydroxy-2-methylpyrrolidine
• CAS: 189149-51-7
• 化学式: C₉H₂₀NO₄P
• 分子量: 237.236
• InChiKey: NVYVCSYVEKEUMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Diethyl (1-hydroxy-2-methylpyrrolidin-2-yl)phosphonate 在 copper diacetate air 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以90%的产率得到5-(二乙氧基磷酰)-5-甲基-1-吡咯啉 N-氧化物
  参考文献：
  名称：

  31P-Labeled Pyrroline N-Oxides: Synthesis of 5-Diethylphosphone-5-methyl-1-pyrroline N-Oxide (DEPMPO) by Oxidation of Diethyl (2-Methylpyrrolidin-2-yl)phosphonate

  摘要：

  DOI：

  10.1055/s-1999-3626
• 作为产物：
  描述：

  5-氯-2-戊酮 在 氨 、 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 反应 2.83h， 生成 Diethyl (1-hydroxy-2-methylpyrrolidin-2-yl)phosphonate
  参考文献：
  名称：

  31P-Labeled Pyrroline N-Oxides: Synthesis of 5-Diethylphosphone-5-methyl-1-pyrroline N-Oxide (DEPMPO) by Oxidation of Diethyl (2-Methylpyrrolidin-2-yl)phosphonate

  摘要：

  DOI：

  10.1055/s-1999-3626

文献信息

• Pestalotiopsis microsporia isolates and compounds derived therefrom
  申请人：——

  公开号：US20040009573A1

  公开（公告）日：2004-01-15

  The present invention relates to the novel isolated 12-30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and derivatives thereof, methods of isolating the novel isobenzofuranone from cultures P. microspora 12-30, and to novel uses of the compound as an antioxidant and antimycotic agent. The present invention further relates to a novel 1,5,7 trisubstituted 1,3-dihydroisobenzofuran and derivatives thereof, methods of isolating this novel compound from cultures of Pestalotiopsis microspora 12-30, and to uses thereof.

  本发明涉及分离出的 12-30 株新型 Pestalotiopsis microspora 本发明涉及能够产生新型抗氧化剂和抗霉菌剂的新型分离菌株 Pestalotiopsis microspora 12-30。本发明还涉及新型分离的 3,5,7-三取代异苯并呋喃酮及其衍生物、从微孢子虫培养物中分离新型异苯并呋喃酮的方法。 P. microspora 12-30 中分离新型异苯并呋喃酮的方法，以及该化合物作为抗氧化剂和抗真菌剂的新用途。本发明进一步涉及一种新型的 1，5，7 三取代的 1，3-二氢异苯并呋喃及其衍生物，从小孢子虫 Pestalotiopsis 的培养物中分离这种新型化合物的方法。 Pestalotiopsis microspora 12-30 及其用途。
• (<i>N</i>-Hydroxy-2-méthylpyrrolidin-2-yl)phosphonate de Diéthyle
  作者：S. Barbati、D. Siri、P. Tordo、J.-P. Reboul

  DOI：10.1107/s0108270196014448

  日期：1997.4.15

  Diethyl (N-hydroxy-2-methylpyrrolidin-2-yl)phosphonate, C9H20NO4P, (II), was isolated as colourless crystals during the oxidation of diethyl (2-methylpyrrolidin-2-yl)phosphonate, (I), with dimethyldioxirane. Compound (II) is the first example of an N-hydroxypyrrolidine ring bearing a beta-phosphorus substituent. The crystal structure analysis reported here was undertaken in order to determine the hybridization state (sp(3)) of the N atom in its hydroxylamine form.
• NITRONES UTILISABLES POUR LE PIEGEAGE DES RADICAUX LIBRES
  申请人：Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP0660841B1

  公开（公告）日：1999-05-26
• US7192939B2
  申请人：——

  公开号：US7192939B2

  公开（公告）日：2007-03-20
• [EN] PESTALOTIOPSIS MICROSPORIA ISOLATES AND COMPOUNDS DERIVED THEREFROM<br/>[FR] ISOLATS DE PESTALOTIOPSIS MICROSPORA ET COMPOSES DERIVES DE CEUX-CI
  申请人：UNIV MONTANA STATE

  公开号：WO2003064617A2

  公开（公告）日：2003-08-07

  The present invention relates to the novel isolated 12-30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and derivatives thereof, methods of isolating the novel isobenzofuranone from cultures P. microspora 12-30, and to novel uses of the compound as an antioxidant and antimycotic agent. The present invention further relates to a novel 1,5,7 trisubstituted 1,3-dihydroisobenzofuran and derivatives thereof, methods of isolating this novel compound from cultures of Pestalotiopsis microspora 12-30, and to uses thereof.