4-trifluoromethylbenzothiophene-3-carboxaldehyde | 916243-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 4-trifluoromethylbenzothiophene-3-carboxaldehyde
• 英文别名: Benzo[b]thiophene-3-carboxaldehyde, 4-(trifluoromethyl)-；4-(trifluoromethyl)-1-benzothiophene-3-carbaldehyde
• CAS: 916243-57-7
• 化学式: C₁₀H₅F₃OS
• 分子量: 230.21
• InChiKey: ADDRMLBWKZJEPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-trifluoromethylbenzothiophene-3-carboxaldehyde 在 磺酰胺 、 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 29.0h， 生成 N-[(4-trifluoromethylbenzo[b]thien-3-yl)methyl]-sulfamide
  参考文献：
  名称：

  CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS

  摘要：

  本发明涉及一种治疗癫痫和相关疾病的方法，包括向需要的受试者施用本文描述的苯并杂环磺酰胺衍生物的治疗有效剂量，以及一种或多种抗惊厥和/或抗癫痫药物的治疗有效剂量的联合治疗。

  公开号：

  US20070293476A1
• 作为产物：
  描述：

  1,1-二氯甲醚 、 苯并[b]噻吩,4-(三氟甲基)- 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 4-trifluoromethylbenzothiophene-3-carboxaldehyde
  参考文献：
  名称：

  Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents

  摘要：

  本发明涉及新型苯并杂环磺酰胺衍生物，含有它们的药物组合物以及它们在治疗癫痫和相关疾病中的应用。

  公开号：

  US20060047001A1

文献信息

• Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
  申请人：Parker H. Michael

  公开号：US20060047001A1

  公开（公告）日：2006-03-02

  The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.

  本发明涉及新型苯并杂环磺酰胺衍生物，含有它们的药物组合物以及它们在治疗癫痫和相关疾病中的应用。
• Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191450A1

  公开（公告）日：2007-08-16

  The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined.

  本发明是一种治疗躁狂症和/或双相情感障碍的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式如下所定义。
• USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191452A1

  公开（公告）日：2007-08-16

  The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined. The present invention is further directed to methods for the treatment of pain comprising co-therapy with analgesic agent(s) and a compound of formula (I) as described herein.

  本发明涉及一种用于治疗疼痛的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺胺衍生物的治疗有效量，其化学式如下所定义。本发明还涉及一种治疗疼痛的方法，包括与镇痛剂联合治疗以及本文描述的化合物的联合治疗。
• Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191460A1

  公开（公告）日：2007-08-16

  The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to methods for the use of benzo-heteroaryl sulfamide derivatives of formula (I) as described herein to therapeutically or prophylactically treat, prevent, reverse, arrest or inhibit epileptogenesis and epilepsy.

  本发明涉及一种治疗、预防、逆转、抑制癫痫或与癫痫有关疾病的发生、发展和成熟的方法。更具体地说，本发明涉及使用如下所述的式(I)的苯并杂环磺酰胺衍生物的方法，用于治疗、预防、逆转、抑制癫痫发生和癫痫。
• USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191461A1

  公开（公告）日：2007-08-16

  The present invention is a method for the treatment or prevention of migraine comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined. The present invention is directed to a method for the treatment and/or prevention of migraine, which includes mono-therapy and alternatively, co-therapy with at least anti-migraine agent

  本发明涉及一种治疗或预防偏头痛的方法，包括向需要的受试者投予根据本处定义的公式(I)的一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量。本发明涉及一种治疗和/或预防偏头痛的方法，包括单独治疗和/或与至少一种抗偏头痛药物联合治疗。