1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-2-buten-1-one | 97024-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-2-buten-1-one
• 英文别名: 1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-2-butenone-1；1-(2-hydroxy-4,5-dimethoxy-phenyl)-3-methyl-but-2-en-1-one；1-(2-Hydroxy-4,5-dimethoxy-phenyl)-3-methyl-but-2-en-1-on；1-(4,5-dimethoxy-2-hydroxyphenyl)-3-methyl-2-buten-1-one；But-2-en-1-one, 1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-；1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methylbut-2-en-1-one
• CAS: 97024-81-2
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: OSURYTKHOFOPLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-2-buten-1-one 在 盐酸 作用下， 以 乙醇 为溶剂， 以5 mg的产率得到6,7-二甲氧基-2,2-二甲基-4-色满酮
  参考文献：
  名称：

  β,β-Dimethacrylophenones and a chromanone from Nama hispidum and N. Johnstonii

  摘要：

  A beta,beta-dimethacrylophenone and the corresponding chromanone were isolated from the leaf resin of Nama hispidum. The leaf exudate of N. johnstonii contains another beta,beta-dimethacrylophenone as colouring matter.

  DOI：

  10.1016/0031-9422(93)85310-n
• 作为产物：
  描述：

  3-甲基巴豆酰氯 、 1,2,4-三甲氧基苯 在 三氯化铝 、 乙醚 、 1,1,2,2-四氯乙烷 作用下， 生成 1-(2-hydroxy-4,5-dimethoxyphenyl)-3-methyl-2-buten-1-one
  参考文献：
  名称：

  Huls, Bulletin des Societes Chimiques Belges, 1958, vol. 67, p. 22,30

  摘要：

  DOI：

文献信息

• Jain, Niveta; Krishnamurty, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 11, p. 1237 - 1241
  作者：Jain, Niveta、Krishnamurty

  DOI：——

  日期：——
• Honokiol Derivates For the Treatment of Proliferative Disorders
  申请人：Arbiser Jack L.

  公开号：US20080300298A1

  公开（公告）日：2008-12-04

  The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used in the prevention and/or treatment of cancer. In particular, honokiol derivatives, pharmaceutical compositions comprising the derivatives, and methods for their use in the treatment of myeloma are provided.
• Vanadyl and vanadate for use in reducing stress-induced metabolic derangement
  申请人：CFM Pharma Holding B.V.

  公开号：US20200246352A1

  公开（公告）日：2020-08-06

  The current invention relates to the use of a physiologically acceptable organic and/or inorganic vanadium compound or complex, such as for example bis(maltolato)oxovanadium (BMOV) in the prevention or amelioration of stress-induced metabolic derangement in a subject. More in particular, the invention relates to a physiologically acceptable organic and/or inorganic vanadium compound or complex for use in the amelioration of hyperglycemia in a subject suffering from stress such as elicited by a trauma, wherein the physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to said subject before the trauma is inflicted to the subject. Furthermore, the invention relates to a physiologically acceptable organic and/or inorganic vanadium compound or complex for use in the prevention of hyperglycemia in a subject having a trauma, wherein the physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to said subject before the subject has the trauma. In one embodiment a physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to a human subject 2 to 24 hours before said human subject is subjected to surgery, for the prevention or amelioration of hyperglycemia elicited by a trauma related to the surgery. It is part of the invention that the physiologically acceptable organic and/or inorganic vanadium compound or complex are a source of vanadyl or vanadate in a patient to whom such compound or complex is administered.
• US5565491A
  申请人：——

  公开号：US5565491A

  公开（公告）日：1996-10-15
• US5583242A
  申请人：——

  公开号：US5583242A

  公开（公告）日：1996-12-10