4-Hydroxy-17α-methyl-19-nor-testosteron | 2747-16-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-Hydroxy-17α-methyl-19-nor-testosteron
• 英文别名: 4-Hydroxy-19-normethyltestosterone；(8R,9S,10R,13S,14S,17S)-4,17-dihydroxy-13,17-dimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 2747-16-2
• 化学式: C₁₉H₂₈O₃
• 分子量: 304.43
• InChiKey: CLNUZOCYKSHICX-FAHHUNKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-17β-hydroxy-17α-methyl-estr-4-en-3-one 在 potassium tert-butylate 作用下， 以 叔丁醇 为溶剂， 生成 4-Hydroxy-17α-methyl-19-nor-testosteron
  参考文献：
  名称：

  Camerino,B. et al., Gazzetta Chimica Italiana, 1962, vol. 92, p. 693 - 708

  摘要：

  DOI：

文献信息

• Ester and ether derivatives of 4-hydroxy-19-nortestosterone and a method for the regulation of athletic function in humans
  申请人：Nutri Sport Pharmacal, Inc.

  公开号：US20030199486A1

  公开（公告）日：2003-10-23

  This invention relates to a method of administering an effective extended release amount of at least one of the ester or ether derivatives of 4-hydroxy-19-nortestosterone for the regulation of athletic function in humans as a dietary supplement.

  本发明涉及一种作为膳食补充剂给药有效缓释量的至少一种 4-羟基-19-去甲睾酮的酯或醚衍生物的方法，用于调节人体的运动功能。
• Use of ester and ether derivatives of 4-hydroxy-19-norandrosterone to increase the level of the anabolic/androgenic hormone 4-hydroxy-19-nortestosterone in humans
  申请人：——

  公开号：US20040002483A1

  公开（公告）日：2004-01-01

  This invention relates to a method of increasing the anabolic/androgenic hormone 4-hydroxy-19-nortestosterone in humans by administering an effective amount of at least one of the ester or ether derivatives of 4-hydroxy-19-norandrosterone.

  本发明涉及一种通过施用有效量的至少一种 4-羟基-19-去甲睾酮的酯或醚衍生物来增加人体同化/雄性激素 4-羟基-19-去甲睾酮的方法。
• PHARMACEUTICAL COMPOSITIONS HAVING NOVEL SCORING PATTERNS AND METHODS OF USING THOSE COMPOSITIONS
  申请人：Solomon Lawrence

  公开号：US20080075772A1

  公开（公告）日：2008-03-27

  The invention provides novel scoring patterns for a wide variety of tablets that contain specific drugs or contain drugs in certain drug classes, and methods of treatment with layered tablets and fractional tablets derived from breaking said tablets.
• Methods of and Compositions For the Prevention of Anxiety, Substance Abuse, and Dependence
  申请人：Sabnani Sanjay

  公开号：US20080207601A1

  公开（公告）日：2008-08-28

  Compositions for reducing dependency and addiction to substances of abuse are provided. Chloride channels such as the GABA A receptors are altered under conditions of dependency and withdrawal such that the electrophysiological properties of the GABA A receptor containing neurons are altered thereby providing a pathophysiological condition resulting in symptoms of dependency and withdrawal such as anxiety. Specifically, under conditions of withdrawal the relative ratio of the a1 receptor subunit decreases relative to the a4 receptor subunit. Endogenous neurosteroid production is also associated with the molecular changes underlying the alterations of GABA-gated chloride channels. Compositions of at least two compounds including at least one inhibitor of neurosteroid production are useful for treating the pathophysiology of addiction, dependency and substance abuse withdrawal.
• SYSTEMS AND METHODS FOR COLLECTING, TRANSPORTING AND REPURPOSING OR DESTROYING UNUSED PHARMACEUTICALS
  申请人：Sharps Compliance, Inc.

  公开号：US20150152348A1

  公开（公告）日：2015-06-04

  Systems and methods implementing the systems including a facility including a plurality of collection apparatuses distributed in the facility for ease of collection and transportation. The system also includes transportation subsystems for shipping filled inner containers to a processing subsystem and for transporting a fuel material or a land fillable material to incineration or landfill subsystems. The systems may also include a monitoring subsystem for monitoring the deployed collection apparatuses, inner containers, the fuel material and the land fillable material.