N,N'-Bis-cyanmethyl-o-phenylendiamin | 94216-83-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-Bis-cyanmethyl-o-phenylendiamin
• 英文别名: o-Phenylendiamin-bisacetonitril；N,N'-o-phenylene-bis-glycine dinitrile；N,N'-o-Phenylen-bis-glycin-dinitril；2,2'-[1,2-Phenylenebis(azanediyl)]diacetonitrile；2-[2-(cyanomethylamino)anilino]acetonitrile
• CAS: 94216-83-8
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.216
• InChiKey: DFCDQVBFOUPTOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-氨基苯胺基)乙腈 、 氰化钠 在 盐酸 、 甲醇 、 聚合甲醛 作用下， 生成 N,N'-Bis-cyanmethyl-o-phenylendiamin
  参考文献：
  名称：

  Sulfaquinoxaline. II. A New Synthesis of 2-Aminoquinoxaline¹

  摘要：

  DOI：

  10.1021/ja01154a143

文献信息

• Signalling compounds for use in methods of detecting hydrogen peroxide
  申请人：——

  公开号：US20040171098A1

  公开（公告）日：2004-09-02

  Compounds useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: 1 is reacted with peroxide. Sig is an aromatic or heteroaromatic ring group, B is a boron atom, and R 5 and R 6 are independently selected from hydrogen and lower alkyl groups and can be joined together as a straight or branched alkylene chain forming a five or six-membered ring. A detectable product compound of the formula Sig-OH Is produced and detected by measuring color, fluorescence, chemiluminescence, or bioluminescence. The signalling compound itself does not possess the detectable property or does so only to a very weak degree. The compounds can be used for detection in assays for peroxide or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.

  本发明揭示了一种用于检测过氧化氢来源的化合物，其中公式1的信号化合物与过氧化物反应。Sig是芳香或杂芳基环团，B是硼原子，R5和R6分别选自氢和低碳基团，并可以连接成直链或支链烷基链形成五元或六元环。产生公式Sig-OH的可检测产物化合物，并通过测量颜色，荧光，化学发光或生物发光来检测。信号化合物本身不具有可检测性或只具有非常弱的可检测性。这些化合物可用于检测过氧化物或产生过氧化物的酶的测定以及使用酶标记的特异性结合对的测定。
• Fluorescent detection of peroxidase enzymes
  申请人：——

  公开号：US20030232405A1

  公开（公告）日：2003-12-18

  Methods of producing fluorescence from fluorogenic substrates reactive with a peroxidase enzyme are disclosed. Use of the methods in assays for peroxidase enzymes, peroxidase-labeled analytes are provided. Fluorogenic compounds, compositions and kits for reaction with peroxidase enzymes are described. Two modes of producing fluorescent compounds are described.

  本发明公开了一种利用与过氧化物酶酶反应的荧光原基产生荧光的方法。本发明提供了将该方法用于过氧化物酶酶的测定和过氧化物酶标记的分析物的方法。本发明还描述了与过氧化物酶酶反应的荧光化合物、组合物和试剂盒。本发明描述了产生荧光化合物的两种方式。
• Signalling compounds and methods for detecting hydrogen peroxide
  申请人：——

  公开号：US20040166539A1

  公开（公告）日：2004-08-26

  Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: 1 is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is independently selected from hydrogen, alkyl and aryl groups and can be joined together as a straight or branched alkylene chain forming a ring or as an aromatic ring. A detectable product compound of the formula Sig-OH or Sig-O − is produced and detected by measuring color, absorbance, fluorescence, chemiluminescence, or bioluminescence. The signalling compound itself does not possess the detectable property or does so only to a very weak degree. The methods can be used as a detectable signal in assays for peroxide or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.

  本发明公开了用于检测过氧化氢来源的方法和化合物，其中含有一种式如下的信号化合物： 1 与过氧化氢反应。Sig 是非聚合有机基团，B 是硼原子，每个 R 独立地选自氢、烷基和芳基，可作为形成环的直链或支链亚烷基链或作为芳香环连接在一起。式 Sig-OH 或 Sig-O - 产生，并通过测量颜色、吸光度、荧光、化学发光或生物发光进行检测。信号化合物本身不具有可检测特性，或仅具有非常微弱的可检测特性。这些方法可在过氧化物或产生过氧化物的酶的检测中以及在采用酶标记的特异性结合对的检测中用作可检测信号。
• FLUORESCENT DETECTION OF PEROXIDASE ENZYMES
  申请人：LUMIGEN, INC.

  公开号：EP1509601B1

  公开（公告）日：2012-12-05
• SIGNALLING COMPOUNDS FOR USE IN METHODS OF DETECTING HYDROGEN PEROXIDE
  申请人：LUMIGEN, INC.

  公开号：EP1594855B1

  公开（公告）日：2014-01-22