6-ethoxy-2,3-dimethyl-quinoxaline 1,4-dioxide | 23465-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-ethoxy-2,3-dimethyl-quinoxaline 1,4-dioxide
• 英文别名: 6-Aethoxy-2,3-dimethyl-chinoxalin-1,4-dioxid；6-ethoxy-2,3-dimethyl-4-oxidoquinoxalin-1-ium 1-oxide
• CAS: 23465-97-6
• 化学式: C₁₂H₁₄N₂O₃
• 分子量: 234.255
• InChiKey: YPMPPUMTNNIGTM-UHFFFAOYSA-N

物化性质

• 沸点：
  449.3±55.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-乙氧基苯-1,2-二胺 在 过氧乙酸 、 溶剂黄146 作用下， 生成 6-ethoxy-2,3-dimethyl-quinoxaline 1,4-dioxide
  参考文献：
  名称：

  Landquist; Stacey, Journal of the Chemical Society, 1953, p. 2822,2827

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING SUBSTANCE INHIBITING ENZYMATIC ACTIVITY OF PEROXIREDOXIN 2 AS EFFECTIVE INGREDIENT FOR TREATMENT OF COLORECTAL CANCER
  申请人：EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

  公开号：US20200129508A1

  公开（公告）日：2020-04-30

  The present invention relates to a pharmaceutical composition for treating colorectal cancer including a material inhibiting the enzyme activity of peroxiredoxin 2 as an active ingredient, and more specifically, to a pharmaceutical composition for treating colorectal cancer, which exhibits the effect of reducing colon polyps via increase of active β-catenin degradation by inhibiting the activity of peroxiredoxin 2, based on the mechanism that promotes colorectal tumor by the interaction between peroxiredoxin 2 (PrxII) and tankyrase (TNKS) in an APC-mutant cell.
• Landquist; Stacey, Journal of the Chemical Society, 1953, p. 2822,2827
  作者：Landquist、Stacey

  DOI：——

  日期：——