Monodesmethylmethotrimeprazin | 108367-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: Monodesmethylmethotrimeprazin
• 英文别名: [3-(2-methoxy-phenothiazin-10-yl)-2-methyl-propyl]-methyl-amine；[γ-(2-methoxy-phenothiazin-10-yl)-isobutyl]-methyl-amine；rac-Normepromazine；3-(2-methoxyphenothiazin-10-yl)-N,2-dimethylpropan-1-amine
• CAS: 108367-20-0
• 化学式: C₁₈H₂₂N₂OS
• 分子量: 314.451
• InChiKey: CIDGBRQEYYPJEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  左美吗嗪盐酸盐 生成 Monodesmethylmethotrimeprazin
  参考文献：
  名称：

  LOENNECHEN, T.;DAHL, S. G., J. CHROMATOGR. , 503,(1990) N, C. 205-215

  摘要：

  DOI：

文献信息

• 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
  申请人：Schnute Edward Mark

  公开号：US20050004161A1

  公开（公告）日：2005-01-06

  The invention provides a compound of formula I: wherein A, B, R 1 , R 2 , R 3 , and R 4 are as defined in the specification. The compounds of the present invention are useful for treating viral infections, in particular a herpesviral infection.

  该发明提供了化合物I的结构，其中A、B、R1、R2、R3和R4如规范中定义。本发明的化合物对治疗病毒感染，特别是单纯疱疹病毒感染，具有实用价值。
• US2837518
  申请人：——

  公开号：——

  公开（公告）日：——
• LOENNECHEN, T.;DAHL, S. G., J. CHROMATOGR. , 503,(1990) N, C. 205-215
  作者：LOENNECHEN, T.、DAHL, S. G.

  DOI：——

  日期：——
• N-desmethyl levomepromazine
  申请人：Moore A. Keith

  公开号：US20050080076A1

  公开（公告）日：2005-04-14

  A pharmaceutically active N-desmethyl levomepromazine (abbreviated NDM LMP) and method of use. NDM LMP has substantially the same therapeutic effects as the parent levomepromazine but is subject to less disposition (e.g. presystemic and systemic metabolism) and thus has improved properties over the parent.
• [EN] 4-OXO-4,7-DIHYDROTHIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS<br/>[FR] 4-OXO-4,7-DIHYDROTHIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES UTILISES COMME AGENTS ANTIVIRAUX
  申请人：PHARMACIA & UPJOHN CO LLC

  公开号：WO2005003140A1

  公开（公告）日：2005-01-13

  The invention provides a compound of Formula (I) wherein A, B, R1, R2, R3, and R4 are as defined in the specification. The compounds of the present invention are useful for treating viral infections, in particular a herpesviral infection.