4-Hydroxy-1-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylphenylacetyl)-1,8-naphthyridin-2(1H)-one | 929612-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Hydroxy-1-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylphenylacetyl)-1,8-naphthyridin-2(1H)-one
• 英文别名: 4-hydroxy-1-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylphenylacetyl)-1,8-naphthyridine-2(1H)-one；4-hydroxy-1-[3-(trifluoromethoxy)phenyl]-3-[2-[4-(trifluoromethyl)phenyl]acetyl]-1,8-naphthyridin-2-one
• CAS: 929612-49-7
• 化学式: C₂₄H₁₄F₆N₂O₄
• 分子量: 508.377
• InChiKey: XOXGDXGKWAAJAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-1-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylphenylacetyl)-1,8-naphthyridin-2(1H)-one 在 肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以32%的产率得到5-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylbenzyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one
  参考文献：
  名称：

  HETEROCYCLIC COMPOUND, AND PRODUCTION PROCESS AND USE THEREOF

  摘要：

  公开号：

  EP1925617B1
• 作为产物：
  描述：

  4-hydroxy-1-(3-trifluoromethoxyphenyl)-1,8-naphthyridin-2(1H)-one 、 2-[4-(三氟甲基)苯基]乙酰氯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以42%的产率得到4-Hydroxy-1-(3-trifluoromethoxyphenyl)-3-(4-trifluoromethylphenylacetyl)-1,8-naphthyridin-2(1H)-one
  参考文献：
  名称：

  HETEROCYCLIC COMPOUND, AND PRODUCTION PROCESS AND USE THEREOF

  摘要：

  公开号：

  EP1925617B1

文献信息

• Heterocycle compound, and production process and application thereof
  申请人：Aska Pharmaceutical Co., Ltd.

  公开号：US08193356B2

  公开（公告）日：2012-06-05

  The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.

  本发明的化合物是一种具有特定杂环骨架的新型化合物，特别是具有通过3位的烷基与5位的碳环键合的有机基团（例如，碳环和杂环）的吡唑啉萘或吡唑喹啉骨架，并具有磷酸二酯酶IV抑制活性。在吡唑啉萘骨架的3位和5位的碳环键合中，至少一个环（碳环或杂环）可能具有卤代烷基和/或卤代烷氧基作为取代基。这样的化合物或其盐对于磷酸二酯酶IV抑制剂等具有用途。根据本发明，可以提供一种具有高磷酸二酯酶IV抑制效果的新型化合物。
• Heterocycle Compound, and Production Process and Application Thereof
  申请人：Kanazawa Hashime

  公开号：US20090131467A1

  公开（公告）日：2009-05-21

  The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.

  本发明的化合物是一种新型化合物，具有特定的杂环骨架，特别是具有通过3位的烷基与5位的碳环键合的有机基团（例如，碳环和杂环）的吡唑萘啶或吡唑喹啉骨架，并具有磷酸二酯酶IV抑制活性。在吡唑萘啶骨架的3位键合的环（碳环或杂环）和5位键合的碳环中，至少有一个可以具有卤代烷基和/或卤代烷氧基作为取代基。这种化合物或其盐可用作磷酸二酯酶IV抑制剂等。根据本发明，可以提供一种具有高磷酸二酯酶IV抑制效果的新型化合物。
• US8193356B2
  申请人：——

  公开号：US8193356B2

  公开（公告）日：2012-06-05
• HETEROCYCLIC COMPOUND, AND PRODUCTION PROCESS AND USE THEREOF
  申请人：ASKA Pharmaceutical Co., Ltd.

  公开号：EP1925617B1

  公开（公告）日：2012-11-14