Isopropyl isopropylphosphonochloridate | 13201-91-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Isopropyl isopropylphosphonochloridate
• 英文别名: isopropyl-phosphonic acid-chloride isopropyl ester；Isopropyl-phosphonsaeure-chlorid-isopropylester；2-[Chloro(propan-2-yl)phosphoryl]oxypropane
• CAS: 13201-91-7
• 化学式: C₆H₁₄ClO₂P
• 分子量: 184.603
• InChiKey: OZTJGOFDNWVSQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Isopropyl isopropylphosphonochloridate 在 silica gel 、 肼 作用下， 以 乙醇 、 苯 为溶剂， 反应 3.5h， 生成
  参考文献：
  名称：

  N,N-二烷基氨基异丙基-和O-烷基异丙基-2-(1-烷基-2-氧代亚丙基)膦酰肼基肟的新型高效合成——潜在的海洋鱼类毒素类似物。第1部分

  摘要：

  已开发出一种使用活性二氧化硅作为脱水剂合成 N,N-二烷基氨基异丙基-和 O-烷基异丙基-2-(1-烷基-2-氧代亚丙基) 膦酰肼基肟 (4) 的新型有效方法。该反应包括取代的二乙酰单肟和 N,N-二烷基氨基异丙基膦酰肼或 O-烷基异丙基膦酰肼的缩合反应，并在温和条件下以优异的产率得到天然存在的鱼毒素的相应类似物。

  DOI：

  10.3390/12071334
• 作为产物：
  描述：

  异丙基二氯磷酸 、 异丙醇 在 三乙胺 作用下， 生成 Isopropyl isopropylphosphonochloridate
  参考文献：
  名称：

  N,N-二烷基氨基异丙基-和O-烷基异丙基-2-(1-烷基-2-氧代亚丙基)膦酰肼基肟的新型高效合成——潜在的海洋鱼类毒素类似物。第1部分

  摘要：

  已开发出一种使用活性二氧化硅作为脱水剂合成 N,N-二烷基氨基异丙基-和 O-烷基异丙基-2-(1-烷基-2-氧代亚丙基) 膦酰肼基肟 (4) 的新型有效方法。该反应包括取代的二乙酰单肟和 N,N-二烷基氨基异丙基膦酰肼或 O-烷基异丙基膦酰肼的缩合反应，并在温和条件下以优异的产率得到天然存在的鱼毒素的相应类似物。

  DOI：

  10.3390/12071334

文献信息

• Tetrabutylammonium tetra (tert-butyl alcohol) coordinated fluoride-an efficient reagent for the synthesis of fluorine derivatives of phosphorus(V) compounds
  作者：Hemendra K. Gupta、Deepak Pardasani、Avik Mazumder、Ajay Kumar Purohit、Devendra K. Dubey

  DOI：10.1016/j.tetlet.2009.03.151

  日期：2009.6

  Direct conversion of phosphorus(V) chlorides to the corresponding phosphorus(V) fluorides was achieved using a solid reagent, tetrabutylammonium tetra (tert-butyl alcohol) coordinated fluoride. The phosphorus(V) fluorides were directly synthesized and efficiently isolated in very good yields.

  使用固体试剂四（叔丁醇）配位的四丁基铵可实现氯化磷（V）直接转化为相应的氟化磷（V）。直接合成了氟（V）氟化物，并以非常高的收率有效地进行了分离。
• Fluorinated phosphorus compounds
  作者：Christopher M Timperley、John F Broderick、Ian Holden、Ian J Morton、Matthew J Waters

  DOI：10.1016/s0022-1139(00)00284-0

  日期：2000.10

  Twenty bis(fluoroalkyl) alkylphosphonates of structure (RFO)2P(O)R were prepared in 28–69% yields by treatment of alkylphosphonic dichlorides Cl2P(O)R [R=Me, Et, n-Pr, i-Pr] with fluoroalcohols RFOH [RF=CF3CH2, H(CF2)2CH2, C2F5CH2, C3H7CH2, (CF3)2CH] in diethyl ether in the presence of triethylamine. Reactions of isopropylphosphonic dichloride with two molar equivalents of alcohols and fluoroalcohols

  二十双（氟代烷基）结构的烷基膦酸酯（R ˚F O）2 P（O）R是在28-69％的收率由处理烷基膦二氯化物的Cl制备2 P（O）R [R =甲基，乙基，Ñ -Pr， i-Pr]与氟代醇R F OH [R F = CF 3 CH 2，H（CF 2）2 CH 2，C 2 F 5 CH 2，C 3 H 7 CH 2，（CF 3）2在乙醚中，在三乙胺的存在下，用CH 2 Cl]。比较了异丙基二氯化膦与两个摩尔当量的醇和氟代醇的反应。在室温下12小时后，醇EtOH，n -PrOH，i-PrOH和n - BuOH给出了单酯和二酯的混合物，但异丙醇除外，后者仅给出了单酯。由烷氧基取代基引起的电子和空间效应令人满意地说明了产物比率。使用氟代醇CF 3 CH 2 OH，C 2 F 5 CH 2 OH，C 3 F 7 CH 2 OH和（CF 3）2CHOH，二酯为主。在此，氟代烷氧基取代基的电子效应稳定了中间体phosphor烷，例如。Cl
• Induction of p53 Accumulation by Moloney Murine Leukemia Virus-ts1 Infection in Astrocytes Via Activation of Extracellular Signal-Regulated Kinases 1/2
  作者：Hun-Taek Kim、Serban Tasca、Wenan Qiang、Paul K Y Wong、George Stoica

  DOI：10.1097/01.lab.0000017373.82871.45

  日期：2002.6

  We previously reported that Moloney murine leukemia virus-ts1-mediated neuronal degeneration in mice is likely a result of both loss of glial support and release of cytokines and neurotoxins from ts1-infected glial cells. Viral infection in some cell types regulates expression of p53 protein, a key regulator of cell proliferation and death. Therefore, we hypothesized that p53 and its dependent genes may be linked with ts1-mediated neuropathology. We examined the presence of p53 and its dependent gene product, a proapoptotic protein bax-alpha, in ts1-induced spongiform encephalomyelopathy. Compared with controls, the lesions of infected animals contained increased levels of p53 and bax-a in astrocytes, as shown by strong nuclear p53 and cytoplasmic bax-alpha immunoreactivity in astrocytes. To determine how ts1 affects p53 expression in astrocytes, we then assessed the expression of p53 and its dependent genes, such as bax-alpha and p21, in infected and uninfected immortalized C1 astrocytes and studied possible pathways responsible for p53 accumulation in infected astrocytes. In these studies using mitogen-activated protein kinase inhibitors, infection-induced increases in the p53 level were partially blocked by PD98059, a synthetic inhibitor of MEK1 that is the immediate upstream kinase of extracellular signal-regulated kinases 1/2 (ERK1/2), but not by SB202190, a potent p38 kinase inhibitor. Furthermore, treatment with PD98059 significantly decreased the level of p21 protein, a p53-dependent gene product. These results suggest that ts1 infection may stabilize p53 protein through activation of ERKs in C1 astrocytes, leading to increased expression of the p21 and bax-alpha proteins, both of which induce cell cycle arrest and apoptosis. Our studies suggest that ts1 neuropathology in mice may result from changes in expression and activity of p53, brought about in part by ts1 activation of ERK.
• METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND GENERATION OF PARTICLES
  申请人：CERULEAN PHARMA INC.

  公开号：US20170362346A1

  公开（公告）日：2017-12-21

  Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.
• A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1
  作者：Rajesh Kumar、Arvind Gupta、Mahabir Kaushik

  DOI：10.3390/12071334

  日期：——

  A novel and efficient method for the synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensation of substituted diacetyl monoxime and N,N-dialkylaminoisopropyl-phosphono hydrazide or O-alkylisopropylphosphono hydrazides and gave the corresponding

  已开发出一种使用活性二氧化硅作为脱水剂合成 N,N-二烷基氨基异丙基-和 O-烷基异丙基-2-(1-烷基-2-氧代亚丙基) 膦酰肼基肟 (4) 的新型有效方法。该反应包括取代的二乙酰单肟和 N,N-二烷基氨基异丙基膦酰肼或 O-烷基异丙基膦酰肼的缩合反应，并在温和条件下以优异的产率得到天然存在的鱼毒素的相应类似物。