fluorescein cadaverine | 56923-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: fluorescein cadaverine
• 英文别名: 5-(5-Aminopentylcarbamothioylamino)-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
• CAS: 56923-81-0
• 化学式: C₂₆H₂₅N₃O₅S
• 分子量: 491.568
• InChiKey: LCXPXAVHHBRFKL-UHFFFAOYSA-N

物化性质

• 沸点：
  765.5±70.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  fluorescein cadaverine 在 N-羟基丁二酰亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 反应 0.34h， 生成 10-(fluoroethoxyphosphinyl)-N-(fluoresceramidopentyl)-decanamide
  参考文献：
  名称：

  Serine/threonine hydrolase proteins and screening assays

  摘要：

  特异于前列腺上皮细胞（正常或肿瘤）的蛋白质已被鉴定并用于诊断、抗体开发以及评估与肿瘤特异蛋白反应的药物。使用亲和力探针与活性位点特异性反应，以提供细胞酶活性的测量。前列腺上皮肿瘤细胞可用于筛选候选药物，以评估其对丝氨酸-苏氨酸水解酶酶的蛋白质组谱影响，使用亲和力探针确定其谱。

  公开号：

  US20060171947A1

文献信息

• IN VIVO METHODS OF MONITORING BIODISTRIBUTION
  申请人：Bovin Nikolai Vladimirovich

  公开号：US20140161723A1

  公开（公告）日：2014-06-12

  Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.

  本发明揭示了结构为F-S-L的功能脂质构造体，其中F包括酪氨酸或组氨酸残基，S是将F与L共价连接的间隔物，而L是脂质。功能残基可以被碘化，并用于用1251放射标记生物实体，而碘化构造体则用于非侵入性方法来监测生物实体在体内的分布。
• In vivo methods of monitoring biodistribution
  申请人：Kode Biotech Limited

  公开号：US10040823B2

  公开（公告）日：2018-08-07

  Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.

  本发明公开了结构为 F-S-L 的功能脂质构建体，其中 F 由酪氨酸或组氨酸残基组成，S 是将 F 与 L 共价连接的间隔物，L 是脂质。该功能残基可被碘化并用于用 1251 对生物实体进行放射性标记，碘化构建物可用于监测生物实体在体内分布的非侵入性方法。
• Structure Determination of an Endogenous Sleep-Inducing Lipid, <i>cis</i>-9-Octadecenamide (Oleamide):  A Synthetic Approach to the Chemical Analysis of Trace Quantities of a Natural Product
  作者：Benjamin F. Cravatt、Richard A. Lerner、Dale L. Boger

  DOI：10.1021/ja9532345

  日期：1996.1.1

  The pursuit of endogenous sleep-inducing substances has been the focus of an extensive, complicated body of research. Several compounds, including Delta-sleep-inducing peptide and prostaglandin D-2, have been suggested to play a role in sleep induction, and yet, the molecular mechanisms of this physiological process remain largely unknown. In recent efforts, the cerebrospinal fluid of deep-deprived cats was analyzed in search of compounds that accumulated during sleep deprivation. An agent with the chemical formula C18H35NO was found to cycle with sleep-wake patterns, increasing in concentration with sleep deprivation and decreasing in amount upon recovery sleep. Since the material was generated in minute quantities and only under the special conditions of sleep deprivation, efforts to isolate sufficient material for adequate characterization, structure identification, and subsequent detailed evaluation of its properties proved unrealistic. With the trace amounts of the impure endogenous compound available, extensive MS studies on the agent were completed, revealing key structural features of the molecule including two degrees of unsaturation, a long alkyl chain, and a nitrogen substituent capable of fragmenting as ammonia. Additionally, HPLC traces suggested a weak UV absorbance for the unknown material. With this data in hand and encouraged by the relatively small size of the molecule, MW = 281, a synthetic approach toward the structural identification of the natural compound was initiated. Herein, we report the full details of the synthesis and comparative characterization of candidate structures for this endogenous agent that led to the unambiguous structural correlation with synthetic cis-9-octadecenamide.
• Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
  申请人：Janjic Jelena

  公开号：US20090074673A1

  公开（公告）日：2009-03-19

  The disclosure provides, in part, compositions and methods for producing cellular labels for tracking cells by MRI. The disclosure provides, in part, methods for labeling, detecting and quantifying cell numbers in vivo.
• VIVO METHODS OF MONITORING BIODISTRIBUTION
  申请人：Kode Biotech Limited

  公开号：US20170240597A1

  公开（公告）日：2017-08-24

  Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.