4-((3,3-diphenylpropyl){[3-(trifluoromethyl)anilino]carbonyl}amino)-N-phenyl-1-piperidine carboxamide | 344790-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((3,3-diphenylpropyl){[3-(trifluoromethyl)anilino]carbonyl}amino)-N-phenyl-1-piperidine carboxamide
• 英文别名: 4-[3,3-diphenylpropyl-[[3-(trifluoromethyl)phenyl]carbamoyl]amino]-N-phenylpiperidine-1-carboxamide
• CAS: 344790-78-9
• 化学式: C₃₅H₃₅F₃N₄O₂
• 分子量: 600.684
• InChiKey: OVMCXGCUQCYFEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(3,3-diphenylpropyl)-N-(4-piperidinyl)-N'-[3-(trifluoromethyl)-phenyl]urea 、 异氰酸苯酯 在 aminomethyl resin 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以40%的产率得到4-((3,3-diphenylpropyl){[3-(trifluoromethyl)anilino]carbonyl}amino)-N-phenyl-1-piperidine carboxamide
  参考文献：
  名称：

  4-Aminopiperidine and their use as a medicine

  摘要：

  本申请的主题是公式1中4-氨基哌啶的新衍生物，其中R1、R2和R3代表各种基团，并通过液相和固相平行合成方法进行制备。这些产物与某些生长抑素受体的亚型具有良好的亲和力，特别适用于治疗涉及一个或多个生长抑素受体的病理状态或疾病。

  公开号：

  US20040006089A1

文献信息

• Derivatives of 4-aminopiperidine and their use a medicament
  申请人：Thurieau Christophe

  公开号：US20050239796A1

  公开（公告）日：2005-10-27

  A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R 1 , R 2 and R 3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

  本申请的主题是新型4-氨基哌啶衍生物的制备方法，其化学式为其中R1、R2和R3代表不同的基团，采用液相和固相平行合成方法制备。这些产物与某些生长抑素受体的亚型有很好的亲和力，特别适用于治疗某些病理状态或疾病，其中一个（或多个）生长抑素受体参与其中。
• 4-aminopiperidine and their use as a medicine
  申请人：Societe de Conseils de Recherches et d'Applications Scientifiques

  公开号：US07115634B2

  公开（公告）日：2006-10-03

  A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

  本申请的主题是新的4-氨基哌啶衍生物，其化学式中R1、R2和R3代表不同的基团，并通过液相和固相平行的合成方法制备它们。这些产物与某些生长抑素受体亚型具有良好的亲和力，它们特别适用于治疗与一个或多个生长抑素受体有关的病理状态或疾病。
• Derivatives of 4-aminopiperidine and their use as a medicament
  申请人：Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)

  公开号：US07393861B2

  公开（公告）日：2008-07-01

  A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

  本申请的主题是新的4-氨基哌啶衍生物，其化学式为R1、R2和R3分别代表各种基团，并且它们的制备过程通过液相和固相合成方法进行。这些产物具有与某些生长抑素受体亚型良好的亲和力，它们特别适用于治疗其中一个或多个生长抑素受体参与的病理状态或疾病。
• DERIVATIVES OF 4-AMINOPIPERIDINE AND THEIR USE AS A MEDICAMENT
  申请人：THURIEAU Christophe

  公开号：US20110059971A1

  公开（公告）日：2011-03-10

  A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R 1 , R 2 and R 3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

  本申请的主题是公式中R1、R2和R3代表不同基团的新型4-氨基哌啶衍生物及其在液态和固态平行合成方法中的制备过程。这些产物与某些生长抑素受体的亚型具有良好的亲和力，特别适用于治疗某些病理状态或疾病，其中涉及一个（或多个）生长抑素受体。
• US7115634B2
  申请人：——

  公开号：US7115634B2

  公开（公告）日：2006-10-03