1-Hexyl-5-methoxynaphthalene | 873426-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Hexyl-5-methoxynaphthalene
• CAS: 873426-02-9
• 化学式: C₁₇H₂₂O
• 分子量: 242.361
• InChiKey: NJLFLESRHUPQPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Hexyl-5-methoxynaphthalene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 5-Hexylnaphthalen-1-ol
  参考文献：
  名称：

  The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

  摘要：

  For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.09.024
• 作为产物：
  描述：

  5-甲氧基-3,4-二氢-2H-1-萘酮 在 palladium on activated charcoal 、 cerium(III) chloride 作用下， 以 乙醚 、 三甘醇二甲醚 为溶剂， 生成 1-Hexyl-5-methoxynaphthalene
  参考文献：
  名称：

  The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

  摘要：

  For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.09.024