2-Methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methylidene]piperidin-1-yl]ethoxy]quinoline | 586412-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methylidene]piperidin-1-yl]ethoxy]quinoline
• CAS: 586412-22-8
• 化学式: C₂₉H₃₅N₃O
• 分子量: 441.616
• InChiKey: MKUFVNDPCZUWKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  28.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methylidene]piperidin-1-yl]ethoxy]quinoline 在 10% palladium on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2-Methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methyl]piperidin-1-yl]ethoxy]quinoline
  参考文献：
  名称：

  一系列有效的，口服生物利用的5-HT 1受体配体的研究-第二部分

  摘要：

  通过阐述先前报道的一系列双5-HT 1 -SSRI，已经研究了一系列5-（哌啶基乙氧基）喹啉5-HT 1受体配体。这些新化合物显示出不同的体外药理学特征，对5-HT 1A，5-HT 1B和5-HT 1D受体具有强大的亲和力，并且对5-羟色胺转运蛋白具有选择性。此外，它们具有改善的药代动力学特征和中枢神经系统渗透性。

  DOI：

  10.1016/j.bmcl.2008.11.052
• 作为产物：
  描述：

  3-溴苄基膦酸二乙酯 在 盐酸 、 palladium diacetate 、 sodium hydride 、 potassium carbonate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 92.0h， 生成 2-Methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methylidene]piperidin-1-yl]ethoxy]quinoline
  参考文献：
  名称：

  一系列有效的，口服生物利用的5-HT 1受体配体的研究-第二部分

  摘要：

  通过阐述先前报道的一系列双5-HT 1 -SSRI，已经研究了一系列5-（哌啶基乙氧基）喹啉5-HT 1受体配体。这些新化合物显示出不同的体外药理学特征，对5-HT 1A，5-HT 1B和5-HT 1D受体具有强大的亲和力，并且对5-羟色胺转运蛋白具有选择性。此外，它们具有改善的药代动力学特征和中枢神经系统渗透性。

  DOI：

  10.1016/j.bmcl.2008.11.052

文献信息

• Compound possessing affinity at 5ht1-type receptors and use thereof in therapy of cns disorders
  申请人：Smith W Paul

  公开号：US20050107410A1

  公开（公告）日：2005-05-19

  Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH 2 or oxygen and is a single bond; or X is nitrogen, Y is CH 2 and is a single bond; is halogen, hydroxy, cyano, C 1-6 alkyl, haloC 1-6 alkyl or C 1-6 alkoxy; a is 0, 1, 2, 3 or 4; R2 and R3, together with the nitrogen atom to which they are attached, form a nitro group or an optionally substituted 3 to 7 membered heterocyclic group, or R2 and R3 are independently hydrogen, aroyl, C 1-6 alkyl, C 1-6 alkanoyl, fluoroC 1-6 alkanoyl, C 1-6 alkylsulfonyl, fluoroC 1-6 alkylsulfonyl, carbamoyl, C 1-6 alkylcarbamoyl, arylC 1-6 alkyl or a group CO(CH 2 )bNR4R5 wherein b is 1, 2, 3 or 4; and R4 and R5 are independently hydrogen or C 1-6 alkyl, or R4 and R5, together with the nitrogen atom to they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.

  公开了式（I）的化合物及其药学上可接受的盐：其中，A是可选取的取代苯基、萘基、吲哚基、喹啉基、喹唑啉基、吲唑基、异喹啉基或苯并呋喃基；X是碳，Y是CH且为双键；或X是CH，Y是CH2或氧且为单键；或X是氮，Y是CH2且为单键；R1是卤素、羟基、氰基、C1-6烷基、卤代C1-6烷基或C1-6烷氧基；a是0、1、2、3或4；R2和R3与它们所连接的氮原子一起形成硝基基团或可选取的取代的3到7元杂环基团，或R2和R3分别是氢、芳香基、C1-6烷基、C1-6酰基、氟代C1-6酰基、C1-6烷基磺酰基、氟代C1-6烷基磺酰基、氨基、C1-6烷基氨基、芳基C1-6烷基或CO(CH2)bNR4R5基团，其中b是1、2、3或4；R4和R5分别是氢或C1-6烷基，或R4和R5与它们所连接的氮原子一起形成可选取的取代的3到7元杂环基团。还公开了制备该化合物的方法以及该化合物在治疗中的用途，特别是在中枢神经系统疾病如抑郁症和焦虑症方面的用途。
• COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY OF CNS DISORDERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1480972A2

  公开（公告）日：2004-12-01
• [EN] COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY<br/>[FR] COMPOSES PRESENTANT UNE AFFINITE VIS-A-VIS DES RECEPTEURS DU TYPE 5HT1, ET LEUR UTILISATION DANS DES TRAITEMENTS
  申请人：GLAXO GROUP LTD

  公开号：WO2003068760A2

  公开（公告）日：2003-08-21

  Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: (I) wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH2 or oxygen and is a single bond; or X is nitrogen, Y is CH2 and is a single bond; R1 is halogen, hydroxy, cyano, C1-6alkyl, haloC1-6alkyl or C1-6alkoxy; a is 0, 1, 2, 3 or 4; R2 and R3, together with the nitrogen atom to which they are attached, form a nitro group or an optionally substituted 3 to 7 membered heterocyclic group, or R2 and R3 are independently hydrogen, aroyl, C1-6alkyl, C1-6alkanoyl, fluoroC1-6alkanoyl, C1-6alkylsulfonyl, fluoroC1-6alkylsulfonyl, carbamoyl, C1-6alkylcarbamoyl, arylC1-6alkyl or a group CO(CH2)bNR4R5 wherein b is 1, 2, 3 or 4 and R4 and R5 are independently hydrogen or C1-6alkyl, or R4 and R5, together with the nitrogen atom to they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.
• Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands—Part II
  作者：Simon E. Ward、Peter Eddershaw、Sean T. Flynn、Laurie Gordon、Peter J. Lovell、Susan H. Moore、Claire M. Scott、Paul W. Smith、Kevin M. Thewlis、Paul A. Wyman

  DOI：10.1016/j.bmcl.2008.11.052

  日期：2009.1

  A series of 5-(piperidinylethyloxy)quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously. These new compounds display a different in vitro pharmacological profile with potent affinity across the 5-HT1A, 5-HT1B and 5-HT1D receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles

  通过阐述先前报道的一系列双5-HT 1 -SSRI，已经研究了一系列5-（哌啶基乙氧基）喹啉5-HT 1受体配体。这些新化合物显示出不同的体外药理学特征，对5-HT 1A，5-HT 1B和5-HT 1D受体具有强大的亲和力，并且对5-羟色胺转运蛋白具有选择性。此外，它们具有改善的药代动力学特征和中枢神经系统渗透性。