diethyl [4-(chloromethyl)-2,5-dimethylfuran-3-yl]methylphosphonate | 1063634-28-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl [4-(chloromethyl)-2,5-dimethylfuran-3-yl]methylphosphonate
• 英文别名: 3-(chloromethyl)-4-(diethoxyphosphorylmethyl)-2,5-dimethylfuran
• CAS: 1063634-28-5
• 化学式: C₁₂H₂₀ClO₄P
• 分子量: 294.715
• InChiKey: CORYVVPMBUIXTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl [4-(chloromethyl)-2,5-dimethylfuran-3-yl]methylphosphonate 、 丁硫醇 在 sodium ethanolate 作用下， 以 乙醇 、 苯 为溶剂， 以63%的产率得到diethyl [4-(butanesulfanylmethyl)-2,5-dimethylfuran-3-yl]methylphosphonate
  参考文献：
  名称：

  Synthesis of 2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)-4-chloromethylfurans and their reactions with butanethiol and diethylamine

  摘要：

  2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)furans when reacted with the paraformaldehydehydrogen chloride system in the presence of zinc chloride form chloromethyl derivatives. The compounds obtained eagerly react with butanethiol and diethylamine to give the corresponding alkylsulfanylmethyl-and aminomethyl-substituted furylmethylphosphonates unavailable by other ways.

  DOI：

  10.1134/s1070363207090204
• 作为产物：
  描述：

  2,5-dimethyl-3-(diethoxyphosphinoylmethyl)furan 、 聚合甲醛 在 zinc(II) chloride 作用下， 以 氯仿 为溶剂， 反应 1.5h， 以95%的产率得到diethyl [4-(chloromethyl)-2,5-dimethylfuran-3-yl]methylphosphonate
  参考文献：
  名称：

  Synthesis of 2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)-4-chloromethylfurans and their reactions with butanethiol and diethylamine

  摘要：

  2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)furans when reacted with the paraformaldehydehydrogen chloride system in the presence of zinc chloride form chloromethyl derivatives. The compounds obtained eagerly react with butanethiol and diethylamine to give the corresponding alkylsulfanylmethyl-and aminomethyl-substituted furylmethylphosphonates unavailable by other ways.

  DOI：

  10.1134/s1070363207090204

文献信息

• Synthesis of 2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)-4-chloromethylfurans and their reactions with butanethiol and diethylamine
  作者：L. M. Pevzner

  DOI：10.1134/s1070363207090204

  日期：2007.9

  2,5-Dialkyl-3-(diethoxyphosphinoylmethyl)furans when reacted with the paraformaldehydehydrogen chloride system in the presence of zinc chloride form chloromethyl derivatives. The compounds obtained eagerly react with butanethiol and diethylamine to give the corresponding alkylsulfanylmethyl-and aminomethyl-substituted furylmethylphosphonates unavailable by other ways.