2-((4-(diethylamino)-2-hydroxybenzylidene)amino)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one | 1341198-49-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-((4-(diethylamino)-2-hydroxybenzylidene)amino)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one
• CAS: 1341198-49-9
• 化学式: C₃₇H₄₁N₅O₃
• 分子量: 603.764
• InChiKey: DLTXQDSHVOZXPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.61
• 重原子数：
  45.0
• 可旋转键数：
  9.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.43
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-((4-(diethylamino)-2-hydroxybenzylidene)amino)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one 、 氯磷酸二乙酯 以 aq. phosphate buffer 、 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  用x吨衍生物通过羰基磷酸化进行选择性DCP检测。

  摘要：

  罗丹明衍生物（1-2）在各种有机磷酸酯（OPs）中选择性地用氯磷酸二乙酯（DCP）显示双通道“开启”光物理信号，其中螺环开口对应于羰基O-螺环上的磷酸化形成加合物。亲核中心。

  DOI：

  10.1039/d0cc03985c
• 作为产物：
  描述：

  3',6'-二(乙基氨基)-2',7'-二甲基螺[异苯并呋喃-1(3H),9'-[9H]氧杂蒽]-3-酮 在 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 12.0h， 生成 2-((4-(diethylamino)-2-hydroxybenzylidene)amino)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one
  参考文献：
  名称：

  用x吨衍生物通过羰基磷酸化进行选择性DCP检测。

  摘要：

  罗丹明衍生物（1-2）在各种有机磷酸酯（OPs）中选择性地用氯磷酸二乙酯（DCP）显示双通道“开启”光物理信号，其中螺环开口对应于羰基O-螺环上的磷酸化形成加合物。亲核中心。

  DOI：

  10.1039/d0cc03985c

文献信息

• Fluorescent salicylaldehyde hydrazone as selective chemosensor for Zn2+ in aqueous ethanol: a ratiometric approach
  作者：Na Li、Weixin Tang、Yu Xiang、Aijun Tong、Peiyuan Jin、Yong Ju

  DOI：10.1002/bio.1175

  日期：2010.11

  4-N,N-diethylaminosalicylaldehyde hydrazone Schiff base (1) and its analogues (2-6) were synthesized and characterized by NMR, MS and elemental analysis. Compound 1 exhibited ratiometric fluorescent response to Zn2+ over other metal ions in aqueous ethanol solution with neutral buffer. The complexation ratio, site and constant and the effect of pH value and water fraction on its fluorescent response to Zn2+ were investigated. Copyright © 2009 John Wiley & Sons, Ltd.

  合成了4-N,N-二乙氨基水杨醛腙席夫碱(1)及其类似物(2-6)，并通过NMR、MS和元素分析对其进行了表征。在含有中性缓冲液的乙醇水溶液中，化合物 1 对 Zn2+ 表现出相对于其他金属离子的比率荧光响应。研究了络合比、位点和常数以及pH值和水含量对其对Zn2+荧光响应的影响。版权所有 © 2009 约翰·威利父子有限公司
• A Novel Chemosensor Based on Rhodamine Derivative for Colorimetric and Fluorometric Detection of Cu2+ in Aqueous Solution
  作者：Yu Wang、Hai-qiang Wu、Jian-hua Sun、Xiao-ya Liu、Jing Luo、Ming-qing Chen

  DOI：10.1007/s10895-012-1040-6

  日期：2012.5

  A new rhodamine-based reversible chemosensor (2) was synthesized, which exhibits high sensitivity and selectivity for Cu2+ but no significant response toward other competitive metal ions in aqueous solution. Upon the addition of Cu2+, the spirolactam ring of 2 was opened and the solution color changed from colorless to red. Strangely, an unexpected fluorescence quenching was observed, which is contrary

  合成了一种新的基于罗丹明的可逆化学传感器 ( 2 )，它对 Cu 2+表现出高灵敏度和选择性，但对水溶液中的其他竞争性金属离子没有显着响应。加入Cu 2+ 后，2的螺内酰胺环打开，溶液颜色由无色变为红色。奇怪的是，观察到了意外的荧光猝灭，这与大多数基于罗丹明的化学传感器的荧光开启相反。已经提出了可能的新型传感机制。
• Hg(II)-activated emission “turn-on” chemosensors excited by up-conversion nanocrystals: Synthesis, characterization and sensing performance
  作者：Shigang Li、Xiaoyun Zhao、Dongliang Tao、Wenbao Zhang、Kaiyin Zhang

  DOI：10.1016/j.saa.2014.08.109

  日期：2015.2

  In this paper, two emission "turn-on" chemosensors for Hg(II) sensing were designed and synthesized. Up-conversion NaYF4 nanocrystals were prepared and used as the excitation host for both chemosensors. Spectral analysis suggested that there should be an efficient energy transfer between the host and the chemosensors, which was then confirmed by excited state lifetime analysis. Then two sensing systems using this up-conversion host and the two chemosensors were constructed, their sensing performance for Hg(II) ions was then studied. It was found that the probe emission intensity increased with increasing Hg(II) concentrations, showing an emission "turn-on" effect. Good selectivity and linear response were observed from both sensing systems. (C) 2014 Elsevier B.V. All rights reserved.