6-chloro-2-(piperidin-1-yl)benzo[d]thiazole | 51482-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 6-chloro-2-(piperidin-1-yl)benzo[d]thiazole
• 英文别名: 6-chloro-2-piperidin-1-yl-1,3-benzothiazole
• CAS: 51482-97-4
• 化学式: C₁₂H₁₃ClN₂S
• 分子量: 252.768
• InChiKey: AMPMJDZQHGJUFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  piperidine-1-carbothioic acid-(4-chloro-anilide) 在 N,N-二异丙基乙胺 、 溶剂红 43 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 6-chloro-2-(piperidin-1-yl)benzo[d]thiazole
  参考文献：
  名称：

  Eosin Y Catalyzed Visible-Light-Promoted Aerobic Oxidative Cyclization of 2-Aminobenzothiazole

  摘要：

  A mild and efficient one-pot visible light irradiated synthesis of 2-aminobenzothiazole 4(a-l) from arylisothiocyanate 1(a-l) and secondary amines 2 have been reported in presence of eosin Y as an organophotoredox catalyst at room temperature under aerobic condition. This synthesis includes application of air and visible light as inexpensive, readily available, high atom economy, non-toxic and sustainable regents.

  DOI：

  10.5562/cca2632

文献信息

• Copper-catalyzed synthesis of 2-aminobenzothiazoles from 2-iodophenyl isocyanides, potassium sulfide and amines
  作者：Hao Min、Genhua Xiao、Wenjuan Liu、Yun Liang

  DOI：10.1039/c6ob02413k

  日期：——

  A simple and practically useful synthetic method for the synthesis of a variety of 2-aminobenzothiazoles was developed. This methodology could construct one C–N bond and two C–S bonds in a step reaction and provide the desired products in good to perfect yields.

  开发了一种简单而实用的合成方法，用于合成各种2-氨基苯并噻唑。这种方法可以在一步反应中构建一个C–N键和两个C–S键，并以理想的产率提供理想的产物。
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：AC IMMUNE SA

  公开号：WO2022078971A1

  公开（公告）日：2022-04-21

  The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of diseases, disorders and or abnormality associated with misfolding of Tau protein and/or pathological aggregation of Tau (Tubulin associated unit) protein including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD). The present invention also relates to processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, methods using said compounds, combinations comprising said compounds, medicaments containing them, and their uses in diseases, disorders and/or abnormalities associated with misfolding of Tau protein and/or pathological aggregation of Tau (Tubulin associated unit) protein.

  本发明涉及一类新化合物，可用于治疗、缓解或预防一组与Tau蛋白误折叠和/或Tau（微管相关单元）蛋白的病理聚集有关的疾病、疾病和/或异常，包括但不限于神经纤维缠结（NFT），如阿尔茨海默病（AD）。本发明还涉及制备所述化合物的方法，包括所述化合物的制药组合物，使用所述化合物的方法，包括所述化合物的组合物，含有它们的药物以及它们在与Tau蛋白误折叠和/或Tau（微管相关单元）蛋白的病理聚集有关的疾病、疾病和/或异常中的用途。
• Synthesis of 2-N-substituted benzothiazoles via domino condensation-hetero cyclization process, mediated by copper oxide nanoparticles under ligand-free conditions
  作者：G. Satish、K. Harsha Vardhan Reddy、K. Ramesh、K. Karnakar、Y.V.D. Nageswar

  DOI：10.1016/j.tetlet.2012.03.012

  日期：2012.5

  A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been developed by using nanocopper oxide as a recyclable catalyst. The present tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to excellent yields by the reaction of 2-iodo aniline with carbon disulfide and piperidine in presence of KOH as a base and DMSO as a solvent under ligand-free conditions. (C) 2012 Elsevier Ltd. All rights reserved.