N,N-dimethyl-1-(2-(naphthalen-2-yl)imidazo[1,2-a]pyridin-3-yl)methanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-dimethyl-1-(2-(naphthalen-2-yl)imidazo[1,2-a]pyridin-3-yl)methanamine
• 英文别名: N,N-dimethyl-1-(2-naphthalen-2-ylimidazo[1,2-a]pyridin-3-yl)methanamine
• 化学式: C₂₀H₁₉N₃
• 分子量: 301.391
• InChiKey: BHKSPGLKWRRTBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(naphthalen-2-yl)imidazo[1,2-a]pyridine 、 N,N-二甲基甲酰胺 在 叔丁基过氧化氢 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 癸烷 为溶剂， 反应 12.0h， 以92%的产率得到N,N-dimethyl-1-(2-(naphthalen-2-yl)imidazo[1,2-a]pyridin-3-yl)methanamine
  参考文献：
  名称：

  Aminomethylation of imidazopyridines using N,N-dimethylformamide as an aminomethylating reagent under Cu(II)-catalysis

  摘要：

  N,N-Dimethylformamide has been explored as an aminomethylating reagent in the functionalization of imidazopyridine under Cu(II)-catalysis. A library of aminomethylated imidazopyridines with broad functionalities was synthesized in good yields. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152581

文献信息

• Aminomethylation of imidazopyridines using N,N-dimethylformamide as an aminomethylating reagent under Cu(II)-catalysis
  作者：Payel Ghosh、Sadhanendu Samanta、Sumit Ghosh、Sourav Jana、Alakananda Hajra

  DOI：10.1016/j.tetlet.2020.152581

  日期：2020.12

  N,N-Dimethylformamide has been explored as an aminomethylating reagent in the functionalization of imidazopyridine under Cu(II)-catalysis. A library of aminomethylated imidazopyridines with broad functionalities was synthesized in good yields. (C) 2020 Elsevier Ltd. All rights reserved.