4-(2-iodophenyl)-2-methylenebutanoic acid | 1384898-45-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 4-(2-iodophenyl)-2-methylenebutanoic acid
• 英文别名: 4-(2-Iodophenyl)-2-methylidenebutanoic acid
• CAS: 1384898-45-6
• 化学式: C₁₁H₁₁IO₂
• 分子量: 302.112
• InChiKey: JAHDLGHGOMOLNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-iodophenyl)-2-methylenebutanoic acid 在 palladium diacetate 、 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 N,N-二甲基乙酰胺 、 N,N-二甲基甲酰胺 为溶剂， 生成 1'-methyl-2,3-dihydro-1'H-spiro[indene-1,3'-quinolin]-2'(4'H)-one
  参考文献：
  名称：

  Spirocyclization by Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions: Synthesis of Spirodihydroquinolin-2-ones

  摘要：

  Treatment of a DMA solution of anilide 1 with a catalytic amount of palladium acetate (0.025 equiv) and XPhos (0.05 equiv) in the presence of potassium carbonate (2.0 equiv) at 100 degrees C afforded dihydroquinolin-2-ones spiro-fused to dihydrofuranyl, indolinyl, and indanyl 2 in good to excellent yields. The reaction went through a domino sequence involving a 5-exo-trig Heck cyclization followed by an intramolecular direct C-H functionalization.

  DOI：

  10.1021/ol301616w
• 作为产物：
  描述：

  2-(2-iodophenethyl)malonic acid 在 哌啶 、 吡啶 、 聚合甲醛 作用下， 以 水 为溶剂， 反应 5.0h， 生成 4-(2-iodophenyl)-2-methylenebutanoic acid
  参考文献：
  名称：

  Spirocyclization by Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions: Synthesis of Spirodihydroquinolin-2-ones

  摘要：

  Treatment of a DMA solution of anilide 1 with a catalytic amount of palladium acetate (0.025 equiv) and XPhos (0.05 equiv) in the presence of potassium carbonate (2.0 equiv) at 100 degrees C afforded dihydroquinolin-2-ones spiro-fused to dihydrofuranyl, indolinyl, and indanyl 2 in good to excellent yields. The reaction went through a domino sequence involving a 5-exo-trig Heck cyclization followed by an intramolecular direct C-H functionalization.

  DOI：

  10.1021/ol301616w

文献信息

• [EN] COMPOSITIONS FOR USE IN THE MANUFACTURE OF LENSES<br/>[FR] COMPOSITIONS DESTINEES A LA FABRICATION DE LENTILLES
  申请人：MEDICAL POLYMERS LTD

  公开号：WO2005109041A1

  公开（公告）日：2005-11-17

  The invention relates to a polymeric ophthalmic lens composition suitable for foldable intraocular lens manufacture having a Tg <37 °C derived from one or more monomers of the formula: CH2=C(R)-C(O)-O-(Y)p-(Z)q-Ar wherein: R is selected form H, CH3 or phenyl; Y is an optionally hydroxy-substituted n-alkyl group having (3) or more carbon atoms; p is 0 or 1; Z is an ester or ether linkage; q is 0 or 1; with the proviso that when q is 1, p is also 1 and that when p is 0, q is also 0; and Ar is benzyl, phenyl, or other mono- or polycyclic-aromatic or heteroaromatic group substituted with one or two iodine groups.