7-keto-DHEA | 1139932-08-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7-keto-DHEA
• 英文别名: 3-Hydroxyandrost-5-ene-7,17-dione；(8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17-dione
• CAS: 1139932-08-3
• 化学式: C₁₉H₂₆O₃
• 分子量: 302.414
• InChiKey: KPRGOTLNGIBVFL-NUXMYSMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-keto-DHEA 在 高氯酸 作用下， 以 甲醇 为溶剂， 以86%的产率得到雄甾-3,5二烯-7,17-二酮
  参考文献：
  名称：

  Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione

  摘要：

  The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [H-2(7)] Arimistane was obtained from Arimistane-d (0) by alkaline H/H-2 exchange of the D-2,D-4,D-6,D-8,D-16 protons. The location of the labels was confirmed by NMR spectroscopy. The spatial structures were studied by X-ray diffraction.

  DOI：

  10.1134/s1070363217120520
• 作为产物：
  描述：

  7-keto-DHEA acetate 、 sodium methylate 以 甲醇 、 水 为溶剂， 以100%的产率得到7-keto-DHEA
  参考文献：
  名称：

  Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione

  摘要：

  The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [H-2(7)] Arimistane was obtained from Arimistane-d (0) by alkaline H/H-2 exchange of the D-2,D-4,D-6,D-8,D-16 protons. The location of the labels was confirmed by NMR spectroscopy. The spatial structures were studied by X-ray diffraction.

  DOI：

  10.1134/s1070363217120520

文献信息

• USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES
  申请人：Hollis-Eden Pharmaceuticals Inc.

  公开号：EP1372664A1

  公开（公告）日：2004-01-02
• METHODS AND COMPOUNDS FOR PREPARING 3ALPHA-OXYGEN SUBSTITUTED STEROIDS
  申请人：Harbor BioSciences, Inc.

  公开号：EP2667876A2

  公开（公告）日：2013-12-04
• [EN] USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES<br/>[FR] TRAITEMENT DE DÉFICIENCES AFFECTANT LES GLOBULES SANGUINS
  申请人：HOLLIS EDEN PHARMACEUTICALS

  公开号：WO2002069977A1

  公开（公告）日：2002-09-12

  The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3β-yl)-β-D-glucopyranosiduronate.
• [EN] USE OF 7-ALPHA HYDROXY DHEA AND 7-OXO DHEA FOR TREATING INFLAMMATORY OR FUNCTIONAL INTESTINAL DISEASES<br/>[FR] DERIVES 7-HYDROXYLES ET 7-CETONIQUES DES HORMONES STEROIDES 3-BETA-HYDROXYLEES POUR LE TRAITEMENT DES MALADIES INFLAMMATOIRES OU FONCTIONNELLES DE L'INTESTIN
  申请人：MAYOLY SPINDLER LAB

  公开号：WO2003024460A1

  公开（公告）日：2003-03-27

  Utilisation de dérivés 7-hydroxylés et 7-cétoniques des hormones stéroïdes 3β-hydroxylées pour le préparation d'un médicament destiné à traiter les maladies inflammatoires ou fonctionnelles de l'intestin.
• [EN] TREATMENT SCREENING METHODS<br/>[FR] PROCEDES DE CRIBLAGE DE TRAITEMENTS
  申请人：HOLLIS EDEN PHARMACEUTICALS

  公开号：WO2007030124A2

  公开（公告）日：2007-03-15

  [EN] The invention includes a method to identify a method to enhance survival of a subject that has been exposed to a biological insult such as an ionizing radiation dose of LD_50/30 by treating the exposed subject with a test compound an optionally comparing the results to that obtained using control subjects that had been treated with 3ß, 17ß-dihydroxyandrost-5-ene or other disclosed compounds.
  [FR] La présente invention a trait à un procédé pour l'identification d'une méthode pour améliorer la survie d'un sujet qui a été exposé à une attaque biologique telle qu'une dose de rayonnement ionisant de LD_50/30 par le traitement du sujet exposé avec au moins un composé d'essai et la comparaison éventuelle des résultats à ceux obtenus à l'aide de sujets de groupe témoin qui ont été traités avec du 3ß, 17ß-dihydroxyandrost-5-ène ou d'autres composés de l'invention.