4-chloro-N-(4-chloro-3-isoquinolin-1-ylphenyl)-3-nitrobenzenesulfonamide | 1258282-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-chloro-N-(4-chloro-3-isoquinolin-1-ylphenyl)-3-nitrobenzenesulfonamide
• CAS: 1258282-42-6
• 化学式: C₂₁H₁₃Cl₂N₃O₄S
• 分子量: 474.324
• InChiKey: SEBHRNBLISJVET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-氯-3-硝基苯磺酰氯 、 4-氯-3-(1,6-二氮杂萘-5-基)苯胺 在 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以74%的产率得到4-chloro-N-(4-chloro-3-isoquinolin-1-ylphenyl)-3-nitrobenzenesulfonamide
  参考文献：
  名称：

  [EN] ISOQUINOLINE, QUINOLINE, AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING
  [FR] DÉRIVÉS DE L'ISOQUINOLÉINE, DE LA QUINOLÉINE ET DE LA QUINAZOLÉINE SERVANT D'INHIBITEURS DE SIGNAL HEDGEHOG

  摘要：

  该发明提供了异喹啉、喹啉和喹唑啉衍生物，用于治疗各种疾病、疾病和病理条件，更具体地用于利用异喹啉、喹啉和喹唑啉衍生物来抑制刺猬信号通路，并利用这些化合物来治疗过度增殖性疾病和病理性血管生成。

  公开号：

  WO2010144586A1

文献信息

• ISOQUINOLINE, QUINOLINE, AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING
  申请人：California Capital Equity, LLC

  公开号：EP2440048B1

  公开（公告）日：2015-10-07
• Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
  申请人：Tao Chunlin

  公开号：US20120270858A1

  公开（公告）日：2012-10-25

  The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.
• COMBINATION THERAPY WITH NANOPARTICLE COMPOSITIONS OF TAXANE AND HEDGEHOG INHIBITORS
  申请人：Tao Chunlin

  公开号：US20130045240A1

  公开（公告）日：2013-02-21

  The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a hedgehog inhibitor that inhibits a hedgehog signaling pathway.
• US9345699B2
  申请人：——

  公开号：US9345699B2

  公开（公告）日：2016-05-24
• [EN] ISOQUINOLINE, QUINOLINE, AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING<br/>[FR] DÉRIVÉS DE L'ISOQUINOLÉINE, DE LA QUINOLÉINE ET DE LA QUINAZOLÉINE SERVANT D'INHIBITEURS DE SIGNAL HEDGEHOG
  申请人：ABRAXIS BIOSCIENCE LLC

  公开号：WO2010144586A1

  公开（公告）日：2010-12-16

  The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.

  该发明提供了异喹啉、喹啉和喹唑啉衍生物，用于治疗各种疾病、疾病和病理条件，更具体地用于利用异喹啉、喹啉和喹唑啉衍生物来抑制刺猬信号通路，并利用这些化合物来治疗过度增殖性疾病和病理性血管生成。