N-butyl-N'-methyl-guanidine | 69724-21-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-butyl-N'-methyl-guanidine
• 英文别名: N-Butyl-N'-methyl-guanidin；1-Butyl-2-methylguanidine
• CAS: 69724-21-6
• 化学式: C₆H₁₅N₃
• 分子量: 129.205
• InChiKey: PHTYZALEUSUQOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(n-Butyl)-3-nitroguanidin 在 ammonium hydroxide 、 水 、 锌 作用下， 生成 N-butyl-N'-methyl-guanidine
  参考文献：
  名称：

  Davis; Rosenquist, Journal of the American Chemical Society, 1937, vol. 59, p. 2114

  摘要：

  DOI：

文献信息

• [EN] TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5<br/>[FR] MODULATEURS TÉTRAHYDRO-BENZOIMIDAZOLYLES DE TGR5
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015160772A1

  公开（公告）日：2015-10-22

  The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, X, Z1and Z2 are defined in the specification.

  本发明包括式（I）的化合物。其中：R1、R2、R3、R4、R5、R6、R7、R8、X、Z1和Z2在规范中定义。
• [EN] PRODUCTS AND METHODS FOR THE TREATMENT OF MIXTURES OF WATER AND HYDROPHOBIC LIQUIDS<br/>[FR] PRODUITS ET PROCÉDÉS POUR LE TRAITEMENT DE MÉLANGES D'EAU ET DE LIQUIDES HYDROPHOBES
  申请人：B C RES INC

  公开号：WO2019232629A1

  公开（公告）日：2019-12-12

  Chemical-based methods and products for mitigating the impact of an oil spill are disclosed. The products act by herding, thickening, gelling, and reducing adhesiveness. N-fatty acid amino acid (FA-AA) conjugates display oil-herding behavior when formulated as a free acid in water-miscible organic solvents. A water-miscible organic solvent is not required if the FA-AA conjugate is formulated as a salt. Various salts of FA-AA conjugates are water soluble and can herd oils and increase the thickness of the oil layer. Replacement of the acid group of fatty acid α-amino acid conjugates with other groups that act as hydrogen bond donors and acceptors results in potent phase selective organo-gellants. The oil spill herders can be prepared from bio-based feedstocks and are biodegradable. The oil thickeners or gellants, which are prepared from bio-based feedstocks, have low toxicity, high capacity for oil and reduce the need to use an organic solvent to apply the thickener or gellant to the oil and water mixture in order to gel the oil phase. Formulae (IB), (II), (III)

  本发明涉及化学方法和产品，用于减轻油污泄漏的影响。这些产品通过聚集、增稠、胶化和降低粘性来发挥作用。当N-脂肪酸氨基酸（FA-AA）共轭物被制成水溶性有机溶剂中的自由酸时，它们具有聚集油的行为。如果FA-AA共轭物被制成盐，则不需要水溶性有机溶剂。各种FA-AA共轭物的盐是水溶性的，可以聚集油并增加油层的厚度。将脂肪酸α-氨基酸共轭物的酸基替换为其他作为氢键供体和受体的基团，可以得到有效的相选择性有机胶凝剂。这些油污聚集剂可以从生物基原料制备，并且是可生物降解的。从生物基原料制备的油稠剂或胶凝剂具有低毒性，对油具有高容量，并且减少了使用有机溶剂将稠剂或胶凝剂应用于油水混合物以胶化油相的需要。公式（IB）、（II）、（III）。
• Antifungal agents
  申请人：Balkovec M. James

  公开号：US20080009504A1

  公开（公告）日：2008-01-10

  The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.

  本发明涉及公式I的新型恩福马霉素衍生物及其药学上可接受的盐，它们的合成以及它们作为(1,3)-β-D-葡聚糖合酶抑制剂的用途。本化合物及其药学上可接受的盐，以及包括本化合物及其药学上可接受的盐的制药组合物，有用于治疗或预防抗真菌感染及相关疾病和病况的作用。
• MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF
  申请人：Hans Jeremy

  公开号：US20130109656A1

  公开（公告）日：2013-05-02

  This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

  本发明涉及有丝分裂动力蛋白酶抑制剂，特别是KSP抑制剂，以及制备这些抑制剂的方法。本发明还提供了包括本发明抑制剂的药物组合物，并提供了利用这些抑制剂和药物组合物在治疗和预防各种疾病方面的方法。
• MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF
  申请人：Array BioPharma Inc.

  公开号：US20140018399A1

  公开（公告）日：2014-01-16

  This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

  本发明涉及有丝分裂动力蛋白酶抑制剂，尤其是KSP的抑制剂，以及制备这些抑制剂的方法。本发明还提供了包含本发明抑制剂的药物组合物，以及利用这些抑制剂和药物组合物在治疗和预防各种疾病方面的方法。