9-triisopropylsilyloxynonanal | 234111-46-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 9-triisopropylsilyloxynonanal
• 英文别名: 9-Tri(propan-2-yl)silyloxynonanal
• CAS: 234111-46-7
• 化学式: C₁₈H₃₈O₂Si
• 分子量: 314.584
• InChiKey: AEUGIIMKTRVPMX-UHFFFAOYSA-N

物化性质

• 沸点：
  357.6±25.0 °C(predicted)
• 密度：
  0.859±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.11
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-triisopropylsilyloxynonanal 在 咪唑 、 4-二甲氨基吡啶 、 potassium tert-butylate 、 四丁基氟化铵 、 碘 、 四氯化钛 、 sodium cyanoborohydride 、 对甲苯磺酸 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 、 乙腈 、 苯 为溶剂， 反应 25.0h， 生成 (2R,3S)-2-allyl-3-non-8'-enyloxytetrahydropyran
  参考文献：
  名称：

  Ring-Closing Metathesis in the Synthesis of Large and Medium-Sized Oxacycles. Application to the Synthesis of Polyoxygenated Macrocycles

  摘要：

  Ring-closing olefin metathesis (RCM) catalyzed by Grubbs's ruthenium benzylidene complex 1 is applied to the synthesis of unsaturated rings ranging in size from seven to thirteen members in trans-fused polyether systems. Reaction occurs with great efficiency in the cyclization of oxepene and oxocene rings, but as ring size increases, yields drop. The influence of the final double bond position is also studied. Better yields and milder reaction conditions are observed when an additional oxygen atom is introduced on the diene. This feature has promoted the application of this reaction to the synthesis of polyoxygenated macrocycles (with sizes ranging from 15 to 21 members), with excellent results.

  DOI：

  10.1021/jo9901438
• 作为产物：
  描述：

  (dec-9-en-1-yloxy)triisopropylsilane 在 三丁基膦 、 臭氧 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到9-triisopropylsilyloxynonanal
  参考文献：
  名称：

  Progress toward the synthesis of a biomimetic membrane

  摘要：

  Ubiquinone has antioxidant properties and is important in the conversion of products from glycolysis and the citric acid cycle to ATP. We report the synthesis of the necessary components of a biological membrane mimic that can serve as a model system for elucidating the third step in the prokaryotic biosynthesis of ubiquinone. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00597-9

文献信息

• [EN] NOVEL LIPIDS FOR DELIVERY OF NUCLEIC ACID SEGMENTS<br/>[FR] NOUVEAUX LIPIDES POUR L'ADMINISTRATION DE SEGMENTS D'ACIDE NUCLÉIQUE
  申请人：[en]ASTRAZENECA AB

  公开号：WO2023089522A1

  公开（公告）日：2023-05-25

  Disclosed herein are compounds of Formula (I), Formula (III) or Formula (IIIa), or pharmaceutically acceptable salts thereof, wherein A, L, X1, X2, a, b, R1and R2are as defined herein. Also disclosed are lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a plurality of lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof and a nucleic acid segment; as well as methods for delivering a nucleic acid segment comprising administering a plurality of lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof, and a nucleic acid segment.
• Ring-Closing Metathesis in the Synthesis of Large and Medium-Sized Oxacycles. Application to the Synthesis of Polyoxygenated Macrocycles
  作者：Mercedes Delgado、Julio D. Martín

  DOI：10.1021/jo9901438

  日期：1999.6.1

  Ring-closing olefin metathesis (RCM) catalyzed by Grubbs's ruthenium benzylidene complex 1 is applied to the synthesis of unsaturated rings ranging in size from seven to thirteen members in trans-fused polyether systems. Reaction occurs with great efficiency in the cyclization of oxepene and oxocene rings, but as ring size increases, yields drop. The influence of the final double bond position is also studied. Better yields and milder reaction conditions are observed when an additional oxygen atom is introduced on the diene. This feature has promoted the application of this reaction to the synthesis of polyoxygenated macrocycles (with sizes ranging from 15 to 21 members), with excellent results.
• Progress toward the synthesis of a biomimetic membrane
  作者：Kyle W Gano、David C Myles

  DOI：10.1016/s0040-4039(00)00597-9

  日期：2000.6

  Ubiquinone has antioxidant properties and is important in the conversion of products from glycolysis and the citric acid cycle to ATP. We report the synthesis of the necessary components of a biological membrane mimic that can serve as a model system for elucidating the third step in the prokaryotic biosynthesis of ubiquinone. (C) 2000 Elsevier Science Ltd. All rights reserved.