carbonic acid t-butyl ester 4-hydroxy-1-vinyl-butyl ester | 861216-64-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: carbonic acid t-butyl ester 4-hydroxy-1-vinyl-butyl ester
• 英文别名: Tert-butyl 6-hydroxyhex-1-en-3-yl carbonate
• CAS: 861216-64-0
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: LALNTCSUPQUIEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  carbonic acid t-butyl ester 4-hydroxy-1-vinyl-butyl ester 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.25h， 生成 carbonic acid t-butyl ester 4-hydroxy-4-phenyl-1-vinyl-butyl ester
  参考文献：
  名称：

  Iridium-catalyzed selective N-allylation of hydrazines

  摘要：

  A highly chemo- and regioselective iridium-catalyzed allylic amination is described. The reaction of various hydrazones and hydrazides with allylic carbonates proceeds at ambient temperature in the presence of an [Ir(COD)Cl](2)/pyridine catalyst, ammonium iodide. and diethylzinc to afford the corresponding N-allylation products in high yields with excellent chemo- and regioselectivities. Only the more nucleophilic nitrogen of a given hydrazine, derivative undergoes the C-N bond formation to yield a branched allylic isomer as the exclusive product. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.105
• 作为产物：
  描述：

  carbonic acid t-butyl ester 4-(t-butyl-dimethyl-silanyloxy)-1-vinyl-butyl ester 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以95%的产率得到carbonic acid t-butyl ester 4-hydroxy-1-vinyl-butyl ester
  参考文献：
  名称：

  Iridium-catalyzed selective N-allylation of hydrazines

  摘要：

  A highly chemo- and regioselective iridium-catalyzed allylic amination is described. The reaction of various hydrazones and hydrazides with allylic carbonates proceeds at ambient temperature in the presence of an [Ir(COD)Cl](2)/pyridine catalyst, ammonium iodide. and diethylzinc to afford the corresponding N-allylation products in high yields with excellent chemo- and regioselectivities. Only the more nucleophilic nitrogen of a given hydrazine, derivative undergoes the C-N bond formation to yield a branched allylic isomer as the exclusive product. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.105