1-[3',6'-Bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]-3-[4-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]thiourea | 1351464-32-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-[3',6'-Bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]-3-[4-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]thiourea
• 英文别名: 1-[3',6'-bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]-3-[4-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]thiourea
• CAS: 1351464-32-8
• 化学式: C₅₁H₄₉N₇O₅S
• 分子量: 872.06
• InChiKey: GCYFVZWOBHJEAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  64
• 可旋转键数：
  9
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1-[3',6'-Bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]-3-[4-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]thiourea 在 mercuric(II) nitrate monohydrate 作用下， 以 甲醇 为溶剂， 反应 0.17h， 以91%的产率得到
  参考文献：
  名称：

  A naphthalimide–rhodamine ratiometric fluorescent probe for Hg2+ based on fluorescence resonance energy transfer

  摘要：

  On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine B, a new fluorophore dyads (4) containing rhodamine B and a naphthalimide moiety was synthesized as a ratiometric fluorescent probe for detecting Hg2+ with a broad pH range 5.7-11.0. The selective fluorescence response of 4 to Hg2+ is due to the Hg2+-promoted desulfurization of the thiocarbonyl moiety, leading to the ring-opening of rhodamine B moiety of 4. When 4 was employed at 0.1 mu M with the slit size being 20 nm/20 nm, a low level of Hg2+ (up to 3 x 10(-8) M) can be detected using the system. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2011.07.020
• 作为产物：
  描述：

  4-morpholino-1,8-naphthalic anhydride 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 65.0h， 生成 1-[3',6'-Bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]-3-[4-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]thiourea
  参考文献：
  名称：

  A naphthalimide–rhodamine ratiometric fluorescent probe for Hg2+ based on fluorescence resonance energy transfer

  摘要：

  On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine B, a new fluorophore dyads (4) containing rhodamine B and a naphthalimide moiety was synthesized as a ratiometric fluorescent probe for detecting Hg2+ with a broad pH range 5.7-11.0. The selective fluorescence response of 4 to Hg2+ is due to the Hg2+-promoted desulfurization of the thiocarbonyl moiety, leading to the ring-opening of rhodamine B moiety of 4. When 4 was employed at 0.1 mu M with the slit size being 20 nm/20 nm, a low level of Hg2+ (up to 3 x 10(-8) M) can be detected using the system. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2011.07.020

文献信息

• A novel ratiometric fluorescence probe for hypochlorite detection and its application in cell imaging
  作者：Zhiwei Ma、Xiaopei Chen、Chuanchuan Wang、Quanjian Lv

  DOI：10.1016/j.molstruc.2020.128812

  日期：2020.12

  Abstract A novel ratiometric fluorescence probe (M1) for hypochlorite (ClO−) based on a mechanism of Fluorescent Resonance Energy Transfer (FRET) has been constructed. Probe M1 can be regarded as a difunctional probe for ClO− and Hg2+. Probe M1 exhibited good specificity and sensitivity towards ClO− over other related analytes as along with low detection limit (13.6 nM). Furthermore, it has been successfully

  摘要 基于荧光共振能量转移 (FRET) 机制构建了一种用于次氯酸盐 (ClO−) 的新型比率荧光探针 (M1)。探针 M1 可被视为 ClO− 和 Hg2+ 的双功能探针。与其他相关分析物相比，探针 M1 对 ClO− 表现出良好的特异性和灵敏度，同时检测限低 (13.6 nM)。此外，它已成功用于活的 Eca109 细胞，用于次氯酸盐的荧光成像。