1-甲基环丙烷羧酰胺盐酸盐 | 78104-89-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-甲基环丙烷羧酰胺盐酸盐
• 英文名称: 1-methylcyclopropanecarboximidamide hydrochloride
• 英文别名: imino(1-methylcyclopropyl)methanaminium chloride；1-methylcyclopropanecarboximidamide, monohydrochloride；1-Methylcyclopropanecarboxamidine hydrochloride；[Amino-(1-methylcyclopropyl)methylidene]azanium;chloride；[amino-(1-methylcyclopropyl)methylidene]azanium;chloride
• CAS: 78104-89-9
• 化学式: C₅H₁₀N₂*ClH
• mdl: MFCD09260734
• 分子量: 134.609
• InChiKey: QXMGYZRRRQGAFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.38
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.9
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N'-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-N,N-dimethylformimid amide 、 1-甲基环丙烷羧酰胺盐酸盐 在 sodium hydroxide 作用下， 以 乙二醇甲醚 为溶剂， 反应 1.0h， 生成 4-methyl-5-[2-(1-methyl-cyclopropyl)-pyrimidin-4-yl]-thiazol-2-ylamine
  参考文献：
  名称：

  Organic Compounds

  摘要：

  本发明涉及公式I的化合物及其盐，其中取代基如描述中所定义，以及该化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的应用。

  公开号：

  US20090163469A1
• 作为产物：
  描述：

  1-甲基环丙烷-1-甲酸甲酯 在 三甲基铝 、 氯化铵 作用下， 以 甲苯 为溶剂， 以0.5 g的产率得到1-甲基环丙烷羧酰胺盐酸盐
  参考文献：
  名称：

  EP3061754

  摘要：

  公开号：

文献信息

• Heterocyclic Compound
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20180155333A1

  公开（公告）日：2018-06-07

  The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有促醒素受体拮抗活性的化合物，预计可用作药物，如预防或治疗睡眠障碍、抑郁症、焦虑症、恐慌症、精神分裂症、药物依赖、阿尔茨海默病等的药剂。 本发明涉及由以下式（I）表示的化合物： 其中每个符号如规范中定义，或其盐。
• WDR5-MLL1 INHIBITORS AND MODULATORS
  申请人：Vanderbilt University

  公开号：US20200055824A1

  公开（公告）日：2020-02-20

  Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.

  苯甲酰胺和吡啶甲酰胺，它们在间位被亚胺基、胍基或含杂环基团取代，会破坏WDR5-MLL1蛋白质间相互作用，并可用于制药组合物中，用于治疗受试者中的增殖性疾病和状况，如癌症。
• Organic Compounds
  申请人：Caravatti Giorgio

  公开号：US20090163469A1

  公开（公告）日：2009-06-25

  The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

  本发明涉及公式I的化合物及其盐，其中取代基如描述中所定义，以及该化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的应用。
• Phosphorus esters of alkylcycloalkyl-5-pyrimidinols and control of corn
  申请人：The Dow Chemical Company

  公开号：US04444764A1

  公开（公告）日：1984-04-24

  Compounds of the formulas: ##STR1## wherein R is alkylcycloalkyl having 4 to 6 carbon atoms; R' is hydrogen, alkyl or alkylthio of 1 to 3 carbons; R" is alkyl having 1 to 4 carbon atoms; X is oxygen or sulfur; and R'" is alkyl of 1 to 2 carbons, alkoxy, alkylthio or monoalkylamino, each with 1 to 4 carbon atoms, or phenyl. The novel 1-alkylcycloalkyl pyrimidinols are used in preparing the phosphate compounds which are highly useful corn rootworm control agents and are particularly valuable when applied to the soil, but are also useful applied to foliage of corn. Especially good control is obtained of corn rootworm. The compounds are conveniently applied in the form of a composition containing a pesticidal carrier such as an inert solvent or a finely divided inert solid in which case the composition is preferably granulated. An effective application rate is in the range of about 0.1 to about 5 pounds per acre when soil incorporated, and about 0.5 to about 2000 ppm for foliar applications.

  该化合物的分子式为：##STR1##其中R是具有4到6个碳原子的烷基环烷基；R'是氢，1到3个碳的烷基或烷基硫；R"是具有1到4个碳原子的烷基；X是氧或硫；R'"是1到2个碳的烷基，烷氧基，烷基硫或单烷基氨基，每个原子有1到4个碳，或苯环。新型的1-烷基环烷基嘧啶醇用于制备磷酸盐化合物，这些化合物是高度有效的玉米根虫控制剂，特别是在施用于土壤时非常有价值，但也适用于施用于玉米叶面。特别是对于玉米根虫的控制效果非常好。这些化合物通常以杀虫剂载体的形式施用，例如惰性溶剂或细粉惰性固体，此时，该组合物最好是颗粒状的。有效的施用速率在土壤中为每英亩约0.1到约5磅，叶面施用为约0.5到约2000 ppm。
• Novel Hydantoin Derivatives as Metalloproteinase Inhibitors
  申请人：Gabos Balint

  公开号：US20080293743A1

  公开（公告）日：2008-11-27

  The invention provides compounds of formula (I): wherein R 1 , R 2 , A, A 1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.

  本发明提供了式(I)的化合物：其中R1、R2、A、A1和B如规范中定义；它们的制备过程；含有它们的制药组合物；制备该制药组合物的过程；以及它们在治疗中的使用。这些化合物有助于作为MMP抑制剂。