N-benzoyl-N'-[2]naphthoyl-hydrazine | 109249-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-benzoyl-N'-[2]naphthoyl-hydrazine
• 英文别名: N-Benzoyl-N'-[2]naphthoyl-hydrazin；N'-benzoylnaphthalene-2-carbohydrazide
• CAS: 109249-36-7
• 化学式: C₁₈H₁₄N₂O₂
• 分子量: 290.321
• InChiKey: YQUBIVFMLZZWMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  570.9±23.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-benzoyl-N'-[2]naphthoyl-hydrazine 在 N,N-二异丙基乙胺 、 对甲苯磺酰氯 作用下， 以 乙腈 为溶剂， 生成 2-naphthalen-2-yl-5-phenyl-[1,3,4]oxadiazole
  参考文献：
  名称：

  Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

  摘要：

  A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.139
• 作为产物：
  描述：

  苯甲酰肼 、 2-萘甲酸 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 N-benzoyl-N'-[2]naphthoyl-hydrazine
  参考文献：
  名称：

  Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

  摘要：

  A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.139

文献信息

• Naphthoyl benzhydrazine–decorated binuclear arene Ru(<scp>ii</scp>) complexes as anticancer agents targeting human breast cancer cells
  作者：Arunachalam Abirami、Umapathy Devan、Rengan Ramesh、Arockiam Antony Joseph Velanganni、Jan Grzegorz Małecki

  DOI：10.1039/d3dt02552g

  日期：——

  pseudo-octahedral geometry around the Ru(II) ion. Solution stability studies using UV-Vis spectroscopy evidenced the instantaneous hydrolysis of the complexes to form monoaquated species in a solution of 1 : 9 (v/v) DMSO/phosphate buffer. All the complexes were screened for their in vitro antiproliferative activities against different human breast cancer cells, including MCF-7, SkBr3, MDA-MB-468, MDA-MB-231

  乳腺癌是女性中最危险的癌症，其死亡率在过去十年中有所增加。为了开发更有效和针对特定靶点的乳腺癌药物，合成了六种含有萘甲酰基苯肼配体 (NL1–NL3) 的芳烃钌 ( II ) 配合物 ( 1–6 )，并通过分析和光谱（红外、紫外-可见、核磁共振和HR-MS）方法。1和6的SC-XRD分析证明了配体与钌离子的双N^O二齿结合性质以及Ru( II )离子周围的伪八面体几何形状。使用紫外-可见光谱进行的溶液稳定性研究证明了复合物在 1:9 (v/v) DMSO/磷酸盐缓冲液中瞬时水解形成单水物质。通过 MTT 测定，筛选所有复合物对不同人乳腺癌细胞（包括 MCF-7、SkBr3、MDA-MB-468、MDA-MB-231 和非癌 HEK-293 细胞）的体外抗增殖活性，并且它们表现出良好的癌细胞生长抑制能力和较低的IC 50值。值得注意的是，与临床药物顺铂相比，包含甲氧基和对伞花烯基团的复合物2
• RUBBER COMPOSITION AND PNEUMATIC TIRES
  申请人：Bridgestone Corporation

  公开号：EP0909788A1

  公开（公告）日：1999-04-21

  A rubber composition prepared by compounding 0.05 to 20 parts by weight of at least one selected from substituted hydrazide compounds represented by the following Formulas (I) to (IV) per 100 parts by weight of a rubber component comprising at least one rubber selected from the group consisting of natural rubber and synthetic rubber, and a pneumatic tire using the same: wherein A represents one selected from the group consisting of an aromatic group which may have a substituent, a hydantoin ring which may have a substituent, and a saturated or unsaturated linear hydrocarbon having 1 to 18 carbon atoms; Y represents hydrogen, an amino group, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group, an aromatic group, a pyridyl group or hydrazino group; and R1 to R11 each represent hydrogen, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group or an aromatic group.

  一种橡胶组合物，其制备方法是每 100 重量份由至少一种选自天然橡胶和合成橡胶组的橡胶组成的橡胶组分中混入 0.05 至 20 重量份的至少一种选自下式(I)至(IV)所代表的取代酰肼化合物，以及使用该组合物的充气轮胎： 其中 A 代表选自芳香基团（可具有取代基）、海因环（可具有取代基）和具有 1 至 18 个碳原子的饱和或不饱和线性烃；Y 代表氢、氨基、具有 1 至 18 个碳原子的烷基、环烷基、烯基、芳香基、吡啶基或肼基；R1 至 R11 分别代表氢、具有 1 至 18 个碳原子的烷基、环烷基或芳香基。
• Rubber composition and pneumatic tire
  申请人：Bridgestone Corporation

  公开号：EP1420044A2

  公开（公告）日：2004-05-19

  A hydrazone derivative represented by Formula (V):         ZC(=O)NHN=C(CH3) (CH2CH(CH3)2)     (V) wherein Z represents 3-hydroxy-2-naphthyl, 1-hydroxy-2-naphthyl, 2-hydroxyphenyl or 2,6-dihydroxyphenyl group.

  式 (V) 所代表的腙衍生物： ZC(=O)NHN=C(CH3) (CH2CH(CH3)2) (V) 其中 Z 代表 3-羟基-2-萘基、1-羟基-2-萘基、2-羟基苯基或 2,6-二羟基苯基。
• Grekow; Asen, Zhurnal Obshchei Khimii, 1959, vol. 29, p. 1995,1997; engl. Ausg. S. 1964
  作者：Grekow、Asen

  DOI：——

  日期：——
• Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins
  申请人：Alberte Randall S.

  公开号：US20090124690A1

  公开（公告）日：2009-05-14

  The present invention relates to, in part, novel sulfate and bisphenol compounds useful for the recognition, attachment and growth of unwanted biologics on natural and manmade surfaces. Another aspect of the invention relates to combinatorial libraries for producing the same. Another aspect of the invention relates to pharmaceutical formulations comprising the same.