3',6'-Bis[(4-aminophenyl)methoxy]-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one | 1333505-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3',6'-Bis[(4-aminophenyl)methoxy]-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one
• 英文别名: 3',6'-bis[(4-aminophenyl)methoxy]-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 1333505-23-9
• 化学式: C₃₆H₃₀N₂O₅
• 分子量: 570.645
• InChiKey: VOACEWIEFOHISK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  43
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4,6-O-(1-butylidene)-D-glucopyranose 、 3',6'-Bis[(4-aminophenyl)methoxy]-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one 以 甲醇 为溶剂， 反应 10.0h， 以54%的产率得到3',6'-bis((4-(((4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-propylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)amino)benzyl)oxy)-4',5'-dimethyl-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines

  摘要：

  A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected D-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.06.001
• 作为产物：
  描述：

  4',5'-Dimethyl-3',6'-bis[(4-nitrophenyl)methoxy]spiro[2-benzofuran-3,9'-xanthene]-1-one 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 25.0h， 以50%的产率得到3',6'-Bis[(4-aminophenyl)methoxy]-4',5'-dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines

  摘要：

  A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected D-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.06.001

文献信息

• Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines
  作者：Mani Rajasekar、Sulaiman Mahaboob Khan、Sivasithamparam Niranjali Devaraj、Thangamuthu Mohan Das

  DOI：10.1016/j.carres.2011.06.001

  日期：2011.9

  A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected D-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines. (C) 2011 Elsevier Ltd. All rights reserved.