3'-(3,4-dimethoxyphenyl)-7-methoxyspiro[2H-chromene-3,2'-oxirane]-4-one | 21733-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'-(3,4-dimethoxyphenyl)-7-methoxyspiro[2H-chromene-3,2'-oxirane]-4-one
• CAS: 21733-38-0
• 化学式: C₁₉H₁₈O₆
• 分子量: 342.348
• InChiKey: XIGKYKODGVKECD-UHFFFAOYSA-N

物化性质

• 沸点：
  534.1±50.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3'-(3,4-dimethoxyphenyl)-7-methoxyspiro[2H-chromene-3,2'-oxirane]-4-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 C₁₉H₂₂O₆
  参考文献：
  名称：

  [EN] FUSED TETRACYCLIC COMPOUNDS, COMPOSITIONS AND DIAGNOSTIC APPLICATIONS THEREOF
  [FR] COMPOSÉS TÉTRACYCLIQUES FUSIONNÉS, COMPOSITIONS ET LEURS APPLICATIONS DIAGNOSTIQUES

  摘要：

  The present invention discloses methods of preparation of fluorescent nucleic acid staining agents containing fused tetracyclic, heterocyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, and their applications in the detection of nucleic acids, and assay methods to establish the efficacy of the nucleic acid staining agents as given in formula (I).

  公开号：

  WO2023017548A1
• 作为产物：
  描述：

  7-羟基色满-4-酮 在 盐酸 、 双氧水 、 potassium carbonate 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 44.0h， 生成 3'-(3,4-dimethoxyphenyl)-7-methoxyspiro[2H-chromene-3,2'-oxirane]-4-one
  参考文献：
  名称：

  [EN] FUSED TETRACYCLIC COMPOUNDS, COMPOSITIONS AND DIAGNOSTIC APPLICATIONS THEREOF
  [FR] COMPOSÉS TÉTRACYCLIQUES FUSIONNÉS, COMPOSITIONS ET LEURS APPLICATIONS DIAGNOSTIQUES

  摘要：

  The present invention discloses methods of preparation of fluorescent nucleic acid staining agents containing fused tetracyclic, heterocyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, and their applications in the detection of nucleic acids, and assay methods to establish the efficacy of the nucleic acid staining agents as given in formula (I).

  公开号：

  WO2023017548A1

文献信息

• Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents
  作者：Chiao-Ting Yen、Kyoko Nakagawa-Goto、Tsong-Long Hwang、Pei-Chi Wu、Susan L. Morris-Natschke、Wan-Chun Lai、Kenneth F. Bastow、Fang-Rong Chang、Yang-Chang Wu、Kuo-Hsiung Lee

  DOI：10.1016/j.bmcl.2009.12.041

  日期：2010.2

  The first total synthesis of the naturally occurring tetracyclic homoisoflavonoid brazilein (1) and 14 new analogs (1a-n) is reported. Target compounds and intermediates were assayed for anti-inflammatory effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB, and for cytotoxic activity against nasopharyngeal (KB), vincristine-resistant nasopharyngeal (KBvin), lung (A549) and prostate (DU-145) human cancer cell lines. The most active compound 1b showed potent effects on superoxide anion generation and elastase release with IC50 values of 1.2 and 1.9 mu M, respectively, and was 65 times more potent than phenylmethylsulfonyl fluoride (PMSF), the positive control, in the latter assay. Additionally, 1b exhibited broad spectrum in vitro anticancer activity with IC50 values of 6-11 mu M against the four tested cancer cell lines. (C) 2009 Elsevier Ltd. All rights reserved.
• [EN] FUSED TETRACYCLIC COMPOUNDS, COMPOSITIONS AND DIAGNOSTIC APPLICATIONS THEREOF<br/>[FR] COMPOSÉS TÉTRACYCLIQUES FUSIONNÉS, COMPOSITIONS ET LEURS APPLICATIONS DIAGNOSTIQUES
  申请人：[en]BENAZIR J, Dr Fathima

  公开号：WO2023017548A1

  公开（公告）日：2023-02-16

  The present invention discloses methods of preparation of fluorescent nucleic acid staining agents containing fused tetracyclic, heterocyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, and their applications in the detection of nucleic acids, and assay methods to establish the efficacy of the nucleic acid staining agents as given in formula (I).