1-(3-phenylthiopropynyl)naphthylene | 220316-68-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(3-phenylthiopropynyl)naphthylene
• CAS: 220316-68-7
• 化学式: C₁₉H₁₄S
• 分子量: 274.386
• InChiKey: UMMOMHRYYPPWFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.98
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1-(3-phenylthiopropynyl)naphthylene 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以80%的产率得到1-(3-phenylsulfonylpropynyl)naphthylene
  参考文献：
  名称：

  Synthesis and Biological Activities of Aryl Propargyl Sulfone

  摘要：

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.

  DOI：

  10.1002/jccs.199800118
• 作为产物：
  描述：

  3-(1-萘基)-2-丙炔-1-醇 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.5h， 生成 1-(3-phenylthiopropynyl)naphthylene
  参考文献：
  名称：

  Synthesis and Biological Activities of Aryl Propargyl Sulfone

  摘要：

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.

  DOI：

  10.1002/jccs.199800118

文献信息

• Synthesis and Biological Activities of Aryl Propargyl Sulfone
  作者：Ming-Jung Wu、Chi-Fong Lin、Li-Juan Chang、Pao-Tzu Jing、Tsai-Hui Duh、Wuan-Ting Tseng、Fang-Chen Lee、Shan-Shue Wang、Hsueh-O Chang

  DOI：10.1002/jccs.199800118

  日期：1998.12

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.