Ethyl 2-(2-bicyclo[2.2.1]hept-5-enylmethoxy-ethoxy-oxidophosphaniumyl)acetate | 245725-38-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Ethyl 2-(2-bicyclo[2.2.1]hept-5-enylmethoxy-ethoxy-oxidophosphaniumyl)acetate
• 英文别名: ethyl 2-(2-bicyclo[2.2.1]hept-5-enylmethoxy-ethoxy-oxidophosphaniumyl)acetate
• CAS: 245725-38-6
• 化学式: C₁₄H₂₃O₅P
• 分子量: 302.307
• InChiKey: CRJHVOSFPNEVFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-降冰片烯-2-甲醇 在 三乙胺 作用下， 以 正己烷 为溶剂， 生成 Ethyl 2-(2-bicyclo[2.2.1]hept-5-enylmethoxy-ethoxy-oxidophosphaniumyl)acetate
  参考文献：
  名称：

  Horner−Emmons Synthesis with Minimal Purification Using ROMPGEL:  A Novel High-Loading Matrix for Supported Reagents

  摘要：

  [GRAPHICS]The synthesis and use of two novel high-loading Horner-Emmons ring-opening metathesis polymers are described, alpha,beta-Unsaturated ethyl esters (E:Z > 99:1) and alpha,beta-unsaturated nitriles (E:Z > 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.

  DOI：

  10.1021/ol990694k

文献信息

• Horner−Emmons Synthesis with Minimal Purification Using ROMPGEL:  A Novel High-Loading Matrix for Supported Reagents
  作者：Anthony G. M. Barrett、Susan M. Cramp、Richard S. Roberts、Frederic J. Zecri

  DOI：10.1021/ol990694k

  日期：1999.8.1

  [GRAPHICS]The synthesis and use of two novel high-loading Horner-Emmons ring-opening metathesis polymers are described, alpha,beta-Unsaturated ethyl esters (E:Z > 99:1) and alpha,beta-unsaturated nitriles (E:Z > 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.