2-<3-(1,2-epoxypropyl)>naphthalene | 145233-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-<3-(1,2-epoxypropyl)>naphthalene
• 英文别名: 2-(naphthalen-2-ylmethyl)oxirane
• CAS: 145233-27-8
• 化学式: C₁₃H₁₂O
• mdl: MFCD22414041
• 分子量: 184.238
• InChiKey: UKFXIJGSHYFEJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-苯基哌啶 、 2-<3-(1,2-epoxypropyl)>naphthalene 以 乙醇 为溶剂， 反应 3.0h， 以80%的产率得到(+/-)-2-hydroxy-3-(2-naphthyl)-1-[1-(4-phenylpiperidinyl)]propane
  参考文献：
  名称：

  Acyclic analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport

  摘要：

  Several 1,3-disubstituted propan-2-ols and one alpha,beta-disubstituted ethanol (11i) were synthesized and evaluated as potential acyclic mimics of the vesicular acetylcholine transport inhibitor 2-(4-phenylpiperidinyl)cyclohexanol (1, vesamicol, AH5183). Analogues containing the 4-phenylpiperidyl fragment (11a, 11b) were more potent than those containing the 4-phenylpiperazyl moiety (11e, 11f). Substitution at the second terminal carbon of the propyl (or ethyl) fragment with simple lipophilic aryl substituents yielded potent inhibitors of vesicular acetylcholine storage, including (-)-11a and d-11i, which are equipotent with vesamicol. However, the activity of analogues containing bicyclic aryl groups was susceptible to aryl substitution patterns (11g vs 11h), indicating a definite receptor site topography. In addition, the inhibitory activity of these acyclic analogues was enantioselective, exhibiting a preference, similar to the parent vesamicol, for the levorotatory isomer [(-)-11a vs (+)-11a]. Therefore, the simple lipophilic acyclic vicinal amino alcohols may successfully mimic the biological activity of vesamicol.

  DOI：

  10.1021/jm00112a044
• 作为产物：
  描述：

  2-[3-(1-丙烯基)]萘 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以100%的产率得到2-<3-(1,2-epoxypropyl)>naphthalene
  参考文献：
  名称：

  Acyclic analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport

  摘要：

  Several 1,3-disubstituted propan-2-ols and one alpha,beta-disubstituted ethanol (11i) were synthesized and evaluated as potential acyclic mimics of the vesicular acetylcholine transport inhibitor 2-(4-phenylpiperidinyl)cyclohexanol (1, vesamicol, AH5183). Analogues containing the 4-phenylpiperidyl fragment (11a, 11b) were more potent than those containing the 4-phenylpiperazyl moiety (11e, 11f). Substitution at the second terminal carbon of the propyl (or ethyl) fragment with simple lipophilic aryl substituents yielded potent inhibitors of vesicular acetylcholine storage, including (-)-11a and d-11i, which are equipotent with vesamicol. However, the activity of analogues containing bicyclic aryl groups was susceptible to aryl substitution patterns (11g vs 11h), indicating a definite receptor site topography. In addition, the inhibitory activity of these acyclic analogues was enantioselective, exhibiting a preference, similar to the parent vesamicol, for the levorotatory isomer [(-)-11a vs (+)-11a]. Therefore, the simple lipophilic acyclic vicinal amino alcohols may successfully mimic the biological activity of vesamicol.

  DOI：

  10.1021/jm00112a044

文献信息

• ISOTACTIC POLY(ALKYLENE OXIDE) AND PRODUCTION PROCESS THEREOF
  申请人：NABIKA Masaaki

  公开号：US20110040070A1

  公开（公告）日：2011-02-17

  An isotactic poly(alkylene oxide) containing the defined repeating unit, and having an isotactic triad fraction of 66 to 100%, and number-average molecular weight of 500,000 or more; and a production process thereof, comprising the step of polymerizing an epoxide represented by the defined formula in the presence of a catalyst and an aliphatic compound and/or alicyclic compound.

  一种含有定义的重复单元的同构聚(烷氧基烷基) ，其同构三元组分数为66%至100%，且其数量平均分子量为500,000或更高；以及其生产过程，包括在催化剂和脂肪族化合物和/或脂环族化合物的存在下聚合所述定义公式表示的环氧化合物的步骤。
• Process for preparing a zinc-containing solid catalyst and process for preparing polyalkylene carbonate
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0358326A1

  公开（公告）日：1990-03-14

  A zinc-containing solid catalyst is prepared by contacting zinc oxide with an organic dicarboxylic acid in the presence or absence of an organic solvent under a mechanical pulverization treatment. The catalyst exhibits high catalytic activity in the copolymerization of carbon dioxide with an epoxide to provide a polyalkylene carbonate.

  在有机溶剂存在或不存在的情况下，通过机械粉碎处理使氧化锌与有机二羧酸接触，制备出一种含锌固体催化剂。该催化剂在二氧化碳与环氧化物共聚生成聚碳酸亚烷基酯的过程中表现出很高的催化活性。
• Processes for production of optically active epoxides
  申请人：DAICEL CHEMICAL INDUSTRIES CO., LTD.

  公开号：EP0611826A2

  公开（公告）日：1994-08-24

  A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida, the genus Rhodosporidium, the genus Rhodococcus and the genus Nosardioides. Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon, the genus Geotrichum, the genus Corynebacterium, the genus Micrococcus and the genus Brevibacterium. The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.

  允许微生物或其制剂作用于环氧化物（如 3-氯苯乙烯氧化物）的对映体混合物，并回收光学活性环氧化物产品。能够从环氧化物的对映体混合物中产生光学活性（S）-环氧化物的微生物包括，例如，属于白色念珠菌属、Rhodosporidium 属、Rhodococcus 属和 Nosardioides 属的微生物菌株。能够从所述混合物中产生光学活性（R）-环氧化物的微生物菌株的例子包括属于三孢菌属、革囊菌属、高丽杆菌属、微球菌属和布雷维杆菌属的微生物菌株。从相应的环氧化物对映体混合物中可以高效、简便地获得具有光学活性的环氧化物。
• CURING RESIN COMPOSITION, ADHESIVE EPOXY RESIN PASTE, ADHESIVE EPOXY RESIN SHEET, CONDUCTIVE CONNECTION PASTE, CONDUCTIVE CONNECTION SHEET, AND ELECTRONIC COMPONENT JOINED BODY
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP1584657A1

  公开（公告）日：2005-10-12

  It is an object of the invention to provide a curable resin composition excellent in mechanical strength, heat resistance, moisture resistance, flexibility, resistance to thermal cycles, resistance to solder reflow, dimensional stability, and the like after curing and providing high adhesion reliability and conduction reliability and an adhesive epoxy resin paste, an adhesive epoxy resin sheet, a conductive connection paste, and a conductive connection sheet using the curable resin composition, and an electronic component joined body. The invention relates to a curable resin composition, which contains an epoxy resin, a solid polymer having a functional group to react with the epoxy group and a curing agent for an epoxy resin, no phase separation structure being observed in a matrix of a resin when a cured product is dyed with a heavy metal and observed with a transmission electron microscope.

  本发明的目的是提供一种固化后机械强度、耐热性、防潮性、柔韧性、耐热循环性、耐焊料回流性、尺寸稳定性等性能优异，并具有高粘接可靠性和传导可靠性的可固化树脂组合物，以及使用该可固化树脂组合物的粘接环氧树脂浆料、粘接环氧树脂片、导电连接浆料和导电连接片，以及电子元件连接体。 本发明涉及一种可固化树脂组合物，它包含环氧树脂、具有与环氧基反应的官能团的固体聚合物和环氧树脂固化剂，当用重金属对固化产品进行染色并用透射电子显微镜观察时，在树脂基体中不会观察到相分离结构。
• ORGANIC ZINC CATALYST, AND PROCESS FOR PRODUCTION OF POLY(ALKYLENE CARBONATE) USING THE SAME
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP2017297A1

  公开（公告）日：2009-01-21

  The present invention has for its object to provide a novel organic zinc catalyst showing very high polymerizing activity in the reaction for producing a poly(alkylene carbonate) from carbon dioxide and an epoxide as well as a method of producing a poly(alkylene carbonate) using the same. The present invention provides an organic zinc catalyst to be used for the reaction for producing a poly(alkylene carbonate) from carbon dioxide and an epoxide, which is obtained by reacting a zinc compound, an aliphatic dicarboxylic acid and an aliphatic monocarboxylic acid in a mole ratio of 0.0001 to 0.1 relative to the aliphatic dicarboxylic acid.

  本发明的目的是提供一种新型有机锌催化剂，该催化剂在用二氧化碳和环氧化物生产聚 碳酸烯烃的反应中显示出极高的聚合活性，并提供一种用该催化剂生产聚 碳酸烯烃的方法。 本发明提供了一种有机锌催化剂，可用于由二氧化碳和环氧化物生产聚（碳酸亚烷基酯）的反应，该催化剂是通过锌化合物、脂肪族二羧酸和脂肪族一元羧酸以相对于脂肪族二羧酸 0.0001 至 0.1 的摩尔比进行反应而获得的。