1,1-Diadamantylmethanimine hydrochloride | 618112-36-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-Diadamantylmethanimine hydrochloride
• 英文别名: bis(1-adamantyl)methanimine;hydrochloride
• CAS: 618112-36-0
• 化学式: C₂₁H₃₁N*ClH
• 分子量: 333.945
• InChiKey: KGGBOPKMAPNRKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.86
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  23.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氰基金刚烷 在 盐酸 、 sodium 作用下， 以 正辛烷 、 乙酸乙酯 为溶剂， 以66%的产率得到1,1-Diadamantylmethanimine hydrochloride
  参考文献：
  名称：

  Nitric oxide donors, compositions and methods of use related applications

  摘要：

  该发明描述了新颖的一氧化氮供体和至少含有一个一氧化氮供体的新型组合物。该发明还提供了至少含有一个一氧化氮供体的新型组合物，以及可选地至少含有一个治疗剂。该发明的化合物和组合物也可以与基质结合。该发明还提供了治疗心血管疾病的方法，用于抑制血液暴露于医疗器械引起的血小板聚集和血小板粘附，用于治疗由于异常细胞增殖导致的病理状况；移植排斥、自身免疫、炎症、增殖、过度增殖、血管疾病；用于减少瘢痕组织或抑制伤口收缩，特别是通过给予一氧化氮供体的预防性和/或治疗性治疗以及至少一个治疗剂的组合来治疗再狭窄的方法。该发明还提供了治疗炎症、疼痛、发热、胃肠道疾病、呼吸道疾病和性功能障碍的方法。一氧化氮供体可以捐赠、转移或释放一氧化氮，并/或提高内源性内皮血管舒张因子的水平，并/或刺激内源性一氧化氮的合成和/或是一氧化氮合酶的底物，能够在生理条件下释放一氧化氮或间接地将一氧化氮传递或转移至靶向部位。治疗剂可以选择性地用至少一个NO和/或NO2基（即亚硝基化和/或亚硝化）替代。该发明还提供了至少含有一个一氧化氮供体和/或至少一个治疗剂的新型组合物和试剂盒。

  公开号：

  US20030203915A1
• 作为试剂：
  描述：

  钠 、 1-氰基金刚烷 、 乙酸乙酯 、 盐酸 在 1,1-Diadamantylmethanimine hydrochloride 作用下， 以 正辛烷 、 乙醚 为溶剂， 反应 7.17h， 以to give the title compound (17 g, 66%)的产率得到1,1-Diadamantylmethanimine hydrochloride
  参考文献：
  名称：

  Nitric oxide donors, compositions and methods of use related applications

  摘要：

  该发明描述了新型一氧化氮供体和至少包含一种一氧化氮供体的新型组合物。该发明还提供了包含至少一种一氧化氮供体和（或）至少一种治疗剂的新型组合物。该发明中的化合物和组合物也可以与基质结合。该发明还提供了治疗心血管疾病、抑制血液暴露于医疗设备引起的血小板聚集和粘附、治疗由异常细胞增殖引起的病理状况、移植排斥、自身免疫、炎症、增生、高增生、血管疾病、减少瘢痕组织或抑制创伤收缩、特别是通过给予一氧化氮供体的预防性和/或治疗性治疗至少一种治疗剂的方法，以及治疗炎症、疼痛、发热、胃肠障碍、呼吸系统障碍和性功能障碍的方法。一氧化氮供体可以捐赠、转移或释放一氧化氮，并/或提高内皮源性舒张因子的内源性水平，并/或刺激内源性一氧化氮的合成，并且是一氧化氮合酶的底物，能够在生理条件下释放一氧化氮或间接地向靶点输送或转移一氧化氮。治疗剂可以选择性地用至少一种NO和/或NO2基（即硝酰化和/或硝化）替换。该发明还提供了至少包含一种一氧化氮供体和/或至少一种治疗剂的新型组合物和工具包。

  公开号：

  US20030203915A1

文献信息

• NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE
  申请人：Nitromed, Inc.

  公开号：EP1497268A2

  公开（公告）日：2005-01-19
• EP1497268A4
  申请人：——

  公开号：EP1497268A4

  公开（公告）日：2006-01-18
• [EN] NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE<br/>[FR] DONNEURS DE MONOXYDE D'AZOTE, COMPOSITIONS ET PROCEDES D'UTILISATION, APPLICATIONS CORRESPONDANTES
  申请人：NITROMED INC

  公开号：WO2003086282A2

  公开（公告）日：2003-10-23

  The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.
• Nitric oxide donors, compositions and methods of use related applications
  申请人：——

  公开号：US20030203915A1

  公开（公告）日：2003-10-30

  The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.

  该发明描述了新颖的一氧化氮供体和至少含有一个一氧化氮供体的新型组合物。该发明还提供了至少含有一个一氧化氮供体的新型组合物，以及可选地至少含有一个治疗剂。该发明的化合物和组合物也可以与基质结合。该发明还提供了治疗心血管疾病的方法，用于抑制血液暴露于医疗器械引起的血小板聚集和血小板粘附，用于治疗由于异常细胞增殖导致的病理状况；移植排斥、自身免疫、炎症、增殖、过度增殖、血管疾病；用于减少瘢痕组织或抑制伤口收缩，特别是通过给予一氧化氮供体的预防性和/或治疗性治疗以及至少一个治疗剂的组合来治疗再狭窄的方法。该发明还提供了治疗炎症、疼痛、发热、胃肠道疾病、呼吸道疾病和性功能障碍的方法。一氧化氮供体可以捐赠、转移或释放一氧化氮，并/或提高内源性内皮血管舒张因子的水平，并/或刺激内源性一氧化氮的合成和/或是一氧化氮合酶的底物，能够在生理条件下释放一氧化氮或间接地将一氧化氮传递或转移至靶向部位。治疗剂可以选择性地用至少一个NO和/或NO2基（即亚硝基化和/或亚硝化）替代。该发明还提供了至少含有一个一氧化氮供体和/或至少一个治疗剂的新型组合物和试剂盒。