N-(1,3-dioxoisoindolin-4-yl)benzamide | 70177-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(1,3-dioxoisoindolin-4-yl)benzamide
• 英文别名: 3-Benzamidophthalimid；4-benzoylamino-isoindole-1,3-dione；N-(1,3-Dioxo-isoindolin-4-yl)-benzamid；3-Benzamidophthalimide；N-(1,3-dioxoisoindol-4-yl)benzamide
• CAS: 70177-95-6
• 化学式: C₁₅H₁₀N₂O₃
• 分子量: 266.256
• InChiKey: RIWQHRITWYOASI-UHFFFAOYSA-N

物化性质

• 熔点：
  285 °C
• 密度：
  1.428±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(1,3-dioxoisoindolin-4-yl)benzamide 在 氢氧化钾 作用下， 反应 0.5h， 以72%的产率得到2-Phenyl-4(3H)-quinazolinone-5-carboxylic acid
  参考文献：
  名称：

  2-芳基-4（3H）-喹唑啉酮-5-羧酸

  摘要：

  DOI：

  10.1021/je00049a033
• 作为产物：
  描述：

  3-硝基邻苯二甲酸酐 在 吡啶 、 盐酸 、 水 、 tin(ll) chloride 作用下， 生成 N-(1,3-dioxoisoindolin-4-yl)benzamide
  参考文献：
  名称：

  Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability

  摘要：

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.

  DOI：

  10.1093/geronb/56.4.s206

文献信息

• Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis
  作者：Wei Zhou、Shiliang Li、Weiqiang Lu、Jun Yuan、Yufang Xu、Honglin Li、Jin Huang、Zhenjiang Zhao

  DOI：10.1039/c5md00469a

  日期：——

  RSK2 (p90 ribosomal S6 kinase 2) is a serine/threonine kinase expressed in a variety of cancers. Molecular-targeted inhibition of RSK2 as a potential therapeutic strategy for human cancers has been documented. In this work, a series of isoindole-1,3-dione derivatives as novel RSK2 inhibitors were designed and synthesized from a hit discovered in our previous study. Some compounds were confirmed to

  RSK2（p90核糖体S6激酶2）是在多种癌症中表达的丝氨酸/苏氨酸激酶。已经证明了分子靶向抑制RSK2作为人类癌症的潜在治疗策略。在这项工作中，从我们先前的研究中发现的命中物中，设计并合成了一系列新型RSK2抑制剂异吲哚-1,3-二酮衍生物。已确认某些化合物是中等有效的RSK2抑制剂，IC 50值约为0.5μM。通过分子对接进行结构-活性关系分析和结合模式研究。
• CASWELL L. R.; CHAO A. H.-M., J. CHEM. AND ENG. DATA, 32,(1987) N 3, 389-390
  作者：CASWELL L. R.、 CHAO A. H.-M.

  DOI：——

  日期：——
• Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability
  作者：R. F. Schoeni、V. A. Freedman、R. B. Wallace

  DOI：10.1093/geronb/56.4.s206

  日期：2001.7.1

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.
• 2-Aryl-4(3H)-quinazolinone-5-carboxylic acids
  作者：Lyman R. Caswell、Alice Huey Mei Chao

  DOI：10.1021/je00049a033

  日期：1987.7