methyl o-tolylsulfonylcarbamate | 32324-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl o-tolylsulfonylcarbamate
• 英文别名: O-Methyl-N-o-tolylsulfonylcarbamat；methyl N-(2-methylphenyl)sulfonylcarbamate
• CAS: 32324-27-9
• 化学式: C₉H₁₁NO₄S
• 分子量: 229.257
• InChiKey: CCNTXQQIEONVBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻,对甲苯磺酰胺 、 氯甲酸甲酯 在 三乙胺 作用下， 以 乙腈 为溶剂， 以40%的产率得到methyl o-tolylsulfonylcarbamate
  参考文献：
  名称：

  Synthesis of Benzofused Five-Ring Sultams via Rh-Catalyzed C–H Olefination Directed by an N-Ac-Substituted Sulfonamide Group

  摘要：

  A Rh-catalyzed N-Ac-sulfonamide group directed C-H olefination-cyclization to afford benzofused five-ring sultam is described with high yield and a wide range of substrate scope. The N-acetyl group is a key for this transformation implying that N-H acidity is the major influence. The acetyl group is removed under mild conditions in excellent yield to provide NH-free sultam that can be transformed into various benzofused five-ring sultam analogues via acylation, nucleophilic substitution, and Mitsunobu alkylation.

  DOI：

  10.1021/jo502224d

文献信息

• Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds
  申请人：Sattigeri Viswajanani Jitendra

  公开号：US20090075909A1

  公开（公告）日：2009-03-19

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.

  本发明涉及单糖衍生物作为抗炎药剂。本发明的化合物可用于抑制和预防炎症及相关病理，包括炎症性和自身免疫性疾病，例如支气管哮喘、类风湿关节炎、I 型糖尿病、多发性硬化症、移植排斥或牛皮癣。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘、慢性阻塞性肺病、类风湿关节炎、多发性硬化症、I 型糖尿病、牛皮癣、移植排斥和其他炎症和/或自身免疫性疾病的方法。
• [EN] MONOSACCHARIDE DERIVATIVES<br/>[FR] DERIVES DE MONOSACCHARIDES
  申请人：RANBAXY LAB LTD

  公开号：WO2007063356A2

  公开（公告）日：2007-06-07

  [EN] The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
  [FR] La présente invention a trait à des dérivés de monosaccharides en tant qu'agents anti-inflammatoires. Les composés de l'invention peuvent être utiles pour l'inhibition et la prévention de maladies auto-immunes et de pathologies associées, comprenant des maladies inflammatoires et auto-immunes, par exemple, l'asthme, la polyarthrite rhumatoïde, le diabète de type 1, la sclérose en plaques, le rejet de greffe allogénique ou le psoriasis. La présente invention a également trait à des compositions pharmaceutiques contenant ces dérivés de monosaccharides, ainsi qu'à des procédés de traitement de l'asthme, de la polyarthrite rhumatoïde, de la sclérose en plaques, du diabète de type 1, du psoriasis ou du rejet de greffe allogénique, et d'autres troubles inflammatoires et/ou auto-immuns.
• Synthesis of Benzofused Five-Ring Sultams via Rh-Catalyzed C–H Olefination Directed by an <i>N</i>-Ac-Substituted Sulfonamide Group
  作者：Xueyuan Li、Yi Dong、Fengyu Qu、Gang Liu

  DOI：10.1021/jo502224d

  日期：2015.1.16

  A Rh-catalyzed N-Ac-sulfonamide group directed C-H olefination-cyclization to afford benzofused five-ring sultam is described with high yield and a wide range of substrate scope. The N-acetyl group is a key for this transformation implying that N-H acidity is the major influence. The acetyl group is removed under mild conditions in excellent yield to provide NH-free sultam that can be transformed into various benzofused five-ring sultam analogues via acylation, nucleophilic substitution, and Mitsunobu alkylation.