1-bromo-5-chloro-hexane | 112337-62-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1-bromo-5-chloro-hexane
• 英文别名: 1-Brom-5-chlor-hexan；1-Bromo-5-chlorohexane
• CAS: 112337-62-9
• 化学式: C₆H₁₂BrCl
• 分子量: 199.518
• InChiKey: VKOFYUFRXCWJEG-UHFFFAOYSA-N

物化性质

• 沸点：
  60 °C(Press: 2.5 Torr)
• 密度：
  1.3322 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-bromo-5-chloro-hexane 在 sodium sulfide 、 乙醇 作用下， 生成 2-methyl-thiane
  参考文献：
  名称：

  The Preparation and Physical Properties of Sulfur Compounds Related to Petroleum. II. Cyclic Sulfides¹

  摘要：

  DOI：

  10.1021/ja01152a022
• 作为产物：
  描述：

  5-Chlor-1-hexen 在 氢溴酸 作用下， 生成 1-bromo-5-chloro-hexane
  参考文献：
  名称：

  The Preparation and Physical Properties of Sulfur Compounds Related to Petroleum. II. Cyclic Sulfides¹

  摘要：

  DOI：

  10.1021/ja01152a022

文献信息

• MDR reversal agents
  申请人：American Cyanamid Company

  公开号：US05550149A1

  公开（公告）日：1996-08-27

  Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.

  通式为：##STR1## 其中R.sub.1，R.sub.2，R.sub.3，R.sub.4和R.sub.5如下所述，A是直链或支链（C.sub.2-C.sub.12）烷基或苯基基团，B是公式的基团：##STR2## 该化合物通过增加多药耐药细胞对化疗药物的敏感性，有效地增强化疗抗癌药物的活性。
• VOLYNSKIJ N. P.; PEREPELITCHENKO L. I., NEFTEXIMIYA, 27,(1987) N 2, 266-272
  作者：VOLYNSKIJ N. P.、 PEREPELITCHENKO L. I.

  DOI：——

  日期：——
• Catalyst system for producing ethylene (co) polymer with improved branch distribution
  申请人：Kong Gapgoung

  公开号：US20080132406A1

  公开（公告）日：2008-06-05

  A process for synthesizing a catalyst component for manufacturing ethylene polymer and co-polymer. The present invention provides a process for synthesizing catalyst component (A), comprising forming a complex by contacting the solid intermediate (B) with an aluminum compound represented by formula X 3-n Al(OY) n , and alkyl metal (C), wherein X is halide, Y is a hydrocarbon group or chelating carbonyl group, and wherein 1 is less than or equal to n which is less than or equal to 3, and then contacting the complex with titanium halide having formula TiX 4 wherein X is halide. Solid intermediate (B) is formed by reacting magnesium metal with alkyl halide in the presence of alkoxy aluminum represented by formula Al(OR a ) 3 , silicon halide represented by formula SiX 4 and alkoxy silane represented by formula Si(OR b ) 4 , wherein R a and R b are an aromatic or aliphatic alkyl group and wherein X is halide. Alkyl metal (C) is synthesized by reacting alkyl aluminum compounds represented by formula AlR c 3 with a secondary amine having formula HNR d 2 and then by reacting with alkyl magnesium compounds represented by formula R e MgR f , wherein R c , R d , Re and R f are an aromatic or aliphatic alkyl group. The catalyst component is suitable for producing ethylene polymer and co-polymer with narrow molecular weight distribution as well as improved branching compositional distribution.
• US5387685A
  申请人：——

  公开号：US5387685A

  公开（公告）日：1995-02-07
• US5550149A
  申请人：——

  公开号：US5550149A

  公开（公告）日：1996-08-27