1-biphenylenol | 1078-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-biphenylenol
• 英文别名: 1-Hydroxy-biphenylen；Hydroxybiphenylen；biphenylen-1-ol
• CAS: 1078-07-5
• 化学式: C₁₂H₈O
• 分子量: 168.195
• InChiKey: IBEBNOABFSWZBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-biphenylenol 、 N,N-二乙基氯乙胺 生成 1-(2-Diethylaminoethoxy)biphenylen
  参考文献：
  名称：

  一些带有药效团侧链的联苯衍生物。

  摘要：

  DOI：

  10.1021/jm00300a054
• 作为产物：
  描述：

  联苯烯 生成 1-biphenylenol
  参考文献：
  名称：

  联苯。第十八部分。一些1-取代联苯的制备和反应

  摘要：

  联苯与丁基锂的反应生成1-和2-硫代联苯的混合物，比例约为20：1。该混合物已用于制备以下1-取代的联苯：戊酰基，甲氧羰基，羧基，乙酰基，甲酰基，羟甲基，溴甲基，甲基，羟基，甲氧基，乙酰氧基，烯丙氧基，羧甲氧基和碘。

  DOI：

  10.1039/j39680000328

文献信息

• ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES
  申请人：Ingrassia Laurent

  公开号：US20100076005A1

  公开（公告）日：2010-03-25

  Isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities are disclosed. In particular, compounds of formula (I) or (II), as well as stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, pharmaceutically acceptable salt and/or solvate are encompassed which are useful in the treatment and prophylaxis of cancer. Methods of preparation are also disclosed.

  揭示了具有抗增殖和抗迁移活性的异喹啉生物碱衍生物。具体来说，公开了符合以下化学式(I)或(II)的化合物，以及其立体异构体、互变异构体、消旋体、前药、代谢物、药学上可接受的盐和/或溶剂，这些化合物在癌症的治疗和预防中很有用。还公开了制备方法。
• [EN] NOVEL INITIATORS FOR LIVING CARBOCATIONIC POLYMERIZATION<br/>[FR] NOUVEAUX INITIATEURS DE POLYMÉRISATION CARBOCATIONIQUE VIVANTE
  申请人：KENNEDY JOSEPH

  公开号：WO2017127642A1

  公开（公告）日：2017-07-27

  In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is directed to methods for using these novel compositions as initiators for isobutylene (IB) and other cationically polymerizable monomers, such as styrene and its derivatives. In still other embodiments, the present invention is directed to structurally new, allyl (and chlorine) telechelic PIBs formed from these new initiator compositions and their derivatives (in particular, hydroxyl telechelic PIB and amine telechelic PIB). In yet other embodiments, the present invention is directed to structurally new polyurethanes, polyureas, and polyurethane ureas made using telechelic PIBs formed from these new initiator compositions.

  在各种实施方式中，本发明涉及用于生产明确定义的端基为电离子聚合物的新型低成本引发剂组合物（通过异丁烯的LC+P）。在其他各种实施方式中，本发明涉及将这些新型组合物用作异丁烯（IB）和其他阳离子聚合单体（例如苯乙烯及其衍生物）的引发剂的方法。在其他实施方式中，本发明涉及由这些新型引发剂组合物及其衍生物（特别是羟基端基PIB和胺端基PIB）形成的结构新的烯丙基（和氯）端基PIB。在其他实施方式中，本发明涉及使用从这些新型引发剂组合物形成的端基为电离子聚合物制得的结构新的聚氨酯、聚脲和聚氨酯脲。
• Quinoxaline biphenyl angiotensin II inhibitors
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US05380719A1

  公开（公告）日：1995-01-10

  Angiotensin II inhibition is exhibited by ##STR1## wherein: X is --CH.sub.2 -- or O; R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl; R.sup.1 and R.sup.2 are each independently O or absent; R.sup.3 is hydrogen, alkyl, alkenyl, alkoxy, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, halo, haloalkyl, or haloalkoxy; R.sup.4 is hydrogen, alkyl, alkenyl, alkoxy, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, --R.sup.8 --OH, or --R.sup.8 CO.sub.2 R.sup.9 ; and the remaining symbols are as defined in the specification.

  血管紧张素II抑制作用由##STR1##表现，其中：X是--CH.sub.2--或O; R是氢，烷基，芳基，环烷基，芳基烷基或环烷基烷基; R.sup.1和R.sup.2各自独立地是O或不存在; R.sup.3是氢，烷基，烯基，烷氧基，环烷基，芳基，芳基烷基，环烷基烷基，卤素，卤基烷基或卤基氧基; R.sup.4是氢，烷基，烯基，烷氧基，芳基，环烷基，芳基烷基，环烷基烷基，--R.sup.8--OH或--R.sup.8CO.sub.2R.sup.9; 其余符号如规范中所定义。
• Kinase Inhibitors
  申请人：Van Rompaey Philippe

  公开号：US20090233960A1

  公开（公告）日：2009-09-17

  The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R 1 , R 2 , R 3 , R 31 , n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

  本发明涉及新的AGC激酶抑制剂，特别是公式I、II或III的化合物，或其立体异构体、互变异构体、外消旋体、代谢产物、前药或前制品、盐、水合物或溶剂化物，其中X、R1、R2、R3、R31、n和m在权利要求书中定义。特别地，本发明更具体地涉及ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病中使用这些抑制剂的用途。
• TERPHENYLENE DERIVATIVE, TETRAHALOTERPHENYL DERIVATIVE, AND PROCESSES FOR PRODUCING BOTH
  申请人：Watanabe Makoto

  公开号：US20090023957A1

  公开（公告）日：2009-01-22

  An object of the present invention relates to provision of a terphenylene derivative having excellent oxidation resistance and capable of forming a semiconductor active phase by a coating process and an oxidation-resistant organic semiconductor material using the sane, as well as an organic thin film. The invention relates to production of a terphenylene derivative represented by the formula (1) by tetralithiating a tetrahaloterphenyl derivative with a lithiating agent and subsequently treating the resulting compound with a copper compound: wherein R 1 to R 14 are the same or different and each represents a hydrogen atom, a fluorine atom, a chlorine atom, an aryl group having 4 to 30 carbon atoms, an alkynyl group having 3 to 20 carbon atoms, an alkenyl group having 2 to 30 carbon atoms, an alkyl group having 1 to 20 carbon atoms or a halogenated alkyl group having 1 to 20 carbon atoms, or a diarylamino group having 8 to carbon atoms; and l, m, and n each represents an integer of 0 or 1.

  本发明涉及一种提供具有优异氧化抗性并能通过涂覆过程形成半导体活性相的三苯基乙烯衍生物以及使用该衍生物的抗氧化有机半导体材料，以及有机薄膜。本发明涉及通过使用锂化试剂四锂化四卤代三苯基衍生物，然后用铜化合物处理所得化合物的方法制备由式（1）表示的三苯基乙烯衍生物的生产方法：其中R1至R14相同或不同，分别表示氢原子，氟原子，氯原子，具有4到30个碳原子的芳基基团，具有3到20个碳原子的炔基基团，具有2到30个碳原子的烯基基团，具有1到20个碳原子的烷基基团或具有1到20个碳原子的卤代烷基基团，或具有8到碳原子的二芳胺基团; l，m和n各代表0或1的整数。