3,4-Dihydroxy-1,2-benzophenazin | 57404-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3,4-Dihydroxy-1,2-benzophenazin
• 英文别名: benzo[a]phenazine-5,6-diol；Benzo[a]phenazin-5,6-diol；Benzo[a]phenazine-5,6-diol
• CAS: 57404-69-0
• 化学式: C₁₆H₁₀N₂O₂
• 分子量: 262.268
• InChiKey: JZDSKTMYWGUQCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4-Dihydroxy-1,2-benzophenazin 生成 苯并[a]吩嗪
  参考文献：
  名称：

  Zincke; Wiegand, Justus Liebigs Annalen der Chemie, 1895, vol. 286, p. 82

  摘要：

  DOI：
• 作为产物：
  描述：

  benzo[a]phenazine-5,6-dione 在 氯仿 、 苯肼 作用下， 生成 3,4-Dihydroxy-1,2-benzophenazin
  参考文献：
  名称：

  707.多核杂环系统。第四部分 线性五环化合物

  摘要：

  DOI：

  10.1039/jr9510003211

文献信息

• Age-Related Differences in Hippocampal Extracellular Fluid Glucose Concentration During Behavioral Testing and Following Systemic Glucose Administration
  作者：E. C. McNay、P. E. Gold

  DOI：10.1093/gerona/56.2.b66

  日期：2001.2.1

  Recent evidence indicates that the level of glucose in the brain's extracellular fluid (ECF) is not constant, as traditionally thought, but fluctuates. We determined the effect of aging on hippocampal ECF glucose before, during, and after spatial memory testing. Fischer-344 rats (24 months old) showed a greater decrease in ECF glucose than 3-month-old rats (48% vs 12%); the decrease seen in 24-month-old rats persisted for much longer following testing. These changes were associated with an age-related deficit in spontaneous alternation performance. Following systemic glucose administration, the decrease in ECF glucose was reversed in both aged and young rats, and performance in aged versus young rats following glucose administration did not differ. These findings suggest that increased susceptibility to depletion of ECF glucose in aged rats may contribute to age-related deficits in learning and memory and that administration of glucose may enhance memory by providing additional glucose to the brain at times of increased cognitive demand.
• 344. Polynuclear heterocyclic systems. Part V. 5 : 8-Diazapentaphene
  作者：G. M. Badger、R. Pettit

  DOI：10.1039/jr9520001874

  日期：——
• Experiments with 1,2-Benzophenazine-3,4-quinone. Thermochromic Effects Based on Lactam—Lactim Tautomerism
  作者：Alexander Schönberg、Ahmed Mustafa、Salah Mohamed Abdel Dayem Zayed

  DOI：10.1021/ja01113a046

  日期：1953.9