N-(3-氨基丙基)尸胺 | 56-19-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(3-氨基丙基)尸胺
• 英文名称: aminopropylcadaverine
• 英文别名: N-(3-Amino-propyl)-pentandiyldiamin；aminopropyl diaminopentane；(5-amino-pentyl)-(3-amino-propyl)-amine；N-(3-amino-propyl)cadaverine；N'-(3-aminopropyl)pentane-1,5-diamine
• CAS: 56-19-9
• 化学式: C₈H₂₁N₃
• 分子量: 159.275
• InChiKey: QZBYOYPROVGOGE-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-氰乙基)-1,5-二氨基戊烷 在 镍 氨 、 氢气 作用下， 以 乙醇 为溶剂， 生成 N-(3-氨基丙基)尸胺
  参考文献：
  名称：

  亚精和亚精的类似物。I.通过还原氰基化的α-α-二甲基乙二胺来合成聚乙烯亚胺。

  摘要：

  DOI：

  10.1021/jm00336a006

文献信息

• Salts of triazinic compounds with phosphorus oxyacids, and use of said compounds in self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0537837A1

  公开（公告）日：1993-04-21

  Salts of triazinic compounds with phosphorus oxyacids, having the general formula (I): obtained by salifying oligomeric derivatives of 2,4, 6-triamino-1,3,5-triazine with a phosphorus-containing acid. The compounds with general formula (I) find use in particular as flame-retardant additives.

  三嗪化合物与含磷氧酸盐的盐，其一般式为(I)：通过用含磷酸盐对2,4,6-三氨基-1,3,5-三嗪的寡聚衍生物进行盐化而获得。具有一般式(I)的化合物特别用作阻燃添加剂。
• Novel polyamine analogues as therapeutic and diagnostic agents
  申请人：ORIDIGM CORPORATION

  公开号：EP1085011A1

  公开（公告）日：2001-03-21

  Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating disease where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

  本发明揭示了具有比已知化合物低两个数量级的抑制常数的多胺转运抑制剂。这些多胺类似物是治疗需要抑制多胺转运或其他多胺结合蛋白的疾病的有用药物，例如癌症和血管成形术后的损伤。揭示了获得多胺类似物的新的化学合成方法，包括制备组合多胺库。这些方法产生的类似物具有理想的诊断和研究测定和治疗活性。本发明的测定方法对于高通量筛选与多胺系统相互作用的药物发现目标非常有用。
• Virus-binding particles, virus-separating reagent, separation of viruses, and detection of viruses
  申请人：JSR Corporation

  公开号：US20010009759A1

  公开（公告）日：2001-07-26

  Particles capable of being bound by viruses, having a particle diameter of 0.05 &mgr;m to 300 &mgr;m and having either a cationic group or an anionic group or both at their surfaces. Also disclosed are a method of separating or detecting viruses and a virus-separating reagent, which make use of such particles. The particles enable simultaneous and simple treatment of a large number of specimens by a simple means.

  能够被病毒绑定的微粒，其粒径为0.05微米至300微米，并且在其表面具有阳离子基团或阴离子基团或两者都有。还公开了一种利用这些微粒分离或检测病毒的方法和病毒分离试剂。这些微粒使得通过简单的方法可以同时处理大量的样本。
• Triazinic compounds
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0448774A2

  公开（公告）日：1991-10-02

  Disclosed are triazinic compounds of general formula (I): wherein the various groups R and Z and the subscripts are as defined in claim 1. The compounds of general formula (I) are particularly useful as flame-retardant additives for polymers.

  所公开的是通式（I）的三嗪类化合物： 其中各基团 R 和 Z 以及下标如权利要求 1 所定义。 通式（I）化合物特别适用于聚合物的阻燃添加剂。
• Diamino-s-triazinon derivatives and self-extinguishing polymeric compositions containing them
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0475367A1

  公开（公告）日：1992-03-18

  Disclosed are ameline derivatives of general formula (I): as defined in claim 1 and the use thereof as flame-proofing agents in self-extinguishing polymeric compositions.

  所公开的是通式（I）的酰胺啉衍生物： 及其在自熄性聚合物组合物中作为阻燃剂的用途。