6-epitetracycline | 19369-52-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: 6-epitetracycline
• 英文别名: 6-Epi-tetracyclin；tetracycline；(4aS)-4c-dimethylamino-3,6c,10,12,12a-pentahydroxy-6t-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
• CAS: 19369-52-9
• 化学式: C₂₂H₂₄N₂O₈
• 分子量: 444.441
• InChiKey: OFVLGDICTFRJMM-GCFPGRGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.21
• 重原子数：
  32.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  181.62
• 氢给体数：
  6.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  脱水差向四环素 在 hydroxylase DacO₁ 、 reductase DacO₄ 作用下， 生成 6-epitetracycline
  参考文献：
  名称：

  [EN] METHODS FOR ENGINEERING THERAPEUTICS AND USES THEREOF
  [FR] PROCÉDÉS D'INGÉNIÉRIE D'AGENTS THÉRAPEUTIQUES ET UTILISATIONS ASSOCIÉES

  摘要：

  所披露的主题提供了基因修饰细胞，例如真菌细胞，这些细胞自主地产生和/或分泌一种或多种治疗分子，例如治疗肽、治疗蛋白质或小型治疗分子，在原位。在某些实施例中，本公开提供了生成和分泌四环素及其类似物的基因工程真菌细胞。

  公开号：

  WO2021092589A1

文献信息

• Preventing or reducing photosensitivity and/or phototoxicity reactions to antiinfective medications
  申请人：G.D. SEARLE & CO.

  公开号：EP1384479A1

  公开（公告）日：2004-01-28

  The present invention provides an article of manufacture comprising: (1) a packaging material, and (2) a once-a-day dose medication which causes a photosensitivity and/or a phototoxicity reaction in a patient contained within said packaging material and wherein said packaging material comprises a label which indicated that such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours.

  本发明提供了一种制造品，包括：(1) 一种包装材料；(2) 在所述包装材料中装有一种会导致患者产生光敏反应和/或光毒性反应的一日一次剂量的药物，其中所述包装材料包括一个标签，该标签表明，通过在傍晚或清晨给患者用药，可以防止或减少这种反应。
• Cobalamin compounds useful as antibiotic agents and as imaging agents
  申请人：——

  公开号：US20020042394A1

  公开（公告）日：2002-04-11

  The invention provides cobalamin derivatives linked to an antibiotic and/or an imaging agent, as well as pharmaceutical compositions comprising the compounds and methods for using the compounds in treatment or diagnosis of a microbial infection.

  本发明提供了与抗生素和/或成像剂连接的钴胺衍生物，以及包含这些化合物的药物组合物和使用这些化合物治疗或诊断微生物感染的方法。
• Potassium channel mediated delivery of agents through the blood-brain barrier
  申请人：Black L. Keith

  公开号：US20050089473A1

  公开（公告）日：2005-04-28

  This invention includes pharmaceutical compositions, methods and kits for the treatment or diagnosis of a malignant tumors, including brain tumors, and diseases or disorders characterized by abnormal brain tissue.

  本发明包括用于治疗或诊断恶性肿瘤（包括脑肿瘤）以及以脑组织异常为特征的疾病或紊乱的药物组合物、方法和试剂盒。
• PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO ANTIINFECTIVE MEDICATIONS
  申请人：G.D. SEARLE & CO.

  公开号：EP0741570B1

  公开（公告）日：2003-05-07
• Compositions useful to treat ocular neovascular diseases and macular degeneration
  申请人：Leonard Todd

  公开号：US20060134226A1

  公开（公告）日：2006-06-22

  The present invention provides a composition that includes: (a) xanthophylls; (b) vitamin C; (c) vitamin E; (d) zinc; and (e) copper. The present invention also provides a method of treating macular degeneration in a human, inhibiting angiogenesis in a human, preventing impairment of the vision or for improving impaired vision of a human whose eye has drusen, and/or treating a disease associated with ocular neovascularitis in a human. The methods include administering to a human in need of such treatment an effective amount of the composition of the present invention.