(-)-(S)-bromofosfamide | 146452-37-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: (-)-(S)-bromofosfamide
• 英文别名: (2S)-(2-chloroethylamino)-3-(2-bromoethyl)-1,3,2-oxazaphosphorinane 2-oxide；(S)-(-)-3-(2-bromoethyl)-N-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine-2-amine 2-oxide；CBM-11；2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-3-(2-bromoethyl)-N-(2-chloroethyl)-, 2-oxide, (R)-；(2R)-3-(2-bromoethyl)-N-(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
• CAS: 146452-37-1
• 化学式: C₇H₁₅BrClN₂O₂P
• 分子量: 305.539
• InChiKey: CQEQYBJQFPXKPE-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (-)-(S)-bromofosfamide 在 双氧水 、 臭氧 作用下， 以 丙酮 为溶剂， 反应 4.0h， 以12%的产率得到(-)-trans-4-hydroperoxybromofosfamide
  参考文献：
  名称：

  Synthesis and antitumour activity of stereoisomers of 4-hydroperoxy derivatives of ifosfamide and its bromo analogue

  摘要：

  Racemic mixtures and laevorotatory enantiomers of cis- and trans-4-hydroperoxyifosfamide and 4-hydroperoxybromofosfamide possess high antitumour activity both in vitro and in vivo. However, no major differences in biological activity were observed among these stereoisomers. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(02)01202-8

文献信息

• Synthesis and antitumour activity of stereoisomers of 4-hydroperoxy derivatives of ifosfamide and its bromo analogue
  作者：Konrad Misiura、Daria Szymanowicz、Halina Kusnierczyk、Joanna Wietrzyk、Adam Opolski

  DOI：10.1016/s0014-827x(02)01202-8

  日期：2002.4

  Racemic mixtures and laevorotatory enantiomers of cis- and trans-4-hydroperoxyifosfamide and 4-hydroperoxybromofosfamide possess high antitumour activity both in vitro and in vivo. However, no major differences in biological activity were observed among these stereoisomers. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.