ethyl 2,3-dimethylfuro<3,2-b>pyrrole-5-carboxylate | 145161-85-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡咯
• 英文名称: ethyl 2,3-dimethylfuro<3,2-b>pyrrole-5-carboxylate
• 英文别名: 2,3-Dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester；Ethyl 2,3-dimethylfuro[3,2-b]pyrrole-5-carboxylate；ethyl 2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylate
• CAS: 145161-85-9
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: RGUMNCDJKVARFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2,3-dimethylfuro<3,2-b>pyrrole-5-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以72%的产率得到2,3-dimethylfuro<3,2-b>pyrrole-5-carboxylic acid
  参考文献：
  名称：

  Condensed O-, N-heterocycles by the transformation of azidoacrylates

  摘要：

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

  DOI：

  10.1007/bf00812330
• 作为产物：
  描述：

  4,5-二甲基-2-糠醛 在 乙醇 、 sodium 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 ethyl 2,3-dimethylfuro<3,2-b>pyrrole-5-carboxylate
  参考文献：
  名称：

  Condensed O-, N-heterocycles by the transformation of azidoacrylates

  摘要：

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

  DOI：

  10.1007/bf00812330

文献信息

• Heterocyclic compounds
  申请人：——

  公开号：US20040048878A1

  公开（公告）日：2004-03-11

  Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H 4 receptor, including allergic rhinitis.

  某些噻吡咯基和呋咯咯基化合物被披露为治疗或预防由组胺H4受体介导的疾病和症状，包括过敏性鼻炎。
• Synthesis of N-Phenylsulfonyl Protected Furo[3,2-b]pyrroles
  作者：Vladimír Bobošík、Alžbeta Krutošíková

  DOI：10.1135/cccc19940499

  日期：——

  Protection of nitrogen atom of heterocyclic molecules, such as indole and pyrrole types, enables various reactions of these systems. N-Phenylsulfonyl derivatives, which have been widely used for this purpose, were prepared in the indole series by the reaction of N-sodium and N-lithium salts with benzenesulfonyl chloride. This method requires waterfree and oxygenfree conditions. On the other hand, the phase transfer catalysis conditions used in this work obviates these disadvantages. We therefore selected the latter method for the preparation of variously substituted 4-phenylsulfonylfuro[3,2-b]pyrroles (I - VII) and 1-phenylsulfonylbenzo[b]furo[3,2-b]pyrroles (VIII - IX).

  保护杂环分子中的氮原子，如吲哚和吡咯类，可以使这些系统发生各种反应。已广泛用于此目的的N-苯磺酰衍生物，通过N-钠和N-锂盐与苯磺酰氯反应制备吲哚系列中。该方法需要无水和无氧条件。另一方面，本研究中使用的相转移催化条件消除了这些缺点。因此，我们选择了后一种方法来制备不同取代的4-苯磺酰基呋喃[3,2-b]吡咯（I-VII）和1-苯磺酰基苯并[ b]呋喃[3,2-b]吡咯（VIII-IX）。
• Heterocyclic Compounds
  申请人：Cai Hui

  公开号：US20070185120A1

  公开（公告）日：2007-08-09

  Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H 4 receptor, including allergic rhinitis.

  某些噻吩吡咯基和呋喃吡咯基化合物被披露为用于治疗或预防由组胺H4受体介导的疾病和症状，包括过敏性鼻炎。
• THIENOPYRROLYL AND FURANOPYRROLYL COMPOUNDS AND THEIR USE AS HISTAMINE H4 RECEPTOR LIGANDS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1543011B1

  公开（公告）日：2006-05-03
• US7226938B2
  申请人：——

  公开号：US7226938B2

  公开（公告）日：2007-06-05